胎盘提取液对实验性高脂大鼠的抑制作用及其机制探讨  

Influence of the human placental extract on the inhibition of experimental abnormal lipidemia in rats as well as the possible mechanisms

作　　者：崔文姬[1] 杨景文[2] 吕忠智[3] 

机构地区：[1]天津市第一中心医院心脏介入科,天津30019 [2]白求恩医科大学第一临床学院 [3]白求恩医科大学基础药理研究室

出　　处：《临床心血管病杂志》2001年第1期30-31,共2页Journal of Clinical Cardiology

摘　　要：目的 :观察人胎盘提取液对高脂鼠脂蛋白 -胆固醇代谢及血小板聚集功能的影响。方法 :Wistar大鼠定量给予高脂饲料建立高脂模型 ,用胎盘提取液 4ml/(kg· d)连续灌胃 1 2 d,测定血脂 ,脂蛋白 ;血浆中前列环素 (PGI2 ) ,血栓素 A2 (Tx A2 )含量及血小板最大聚集率 (MA)。结果 :胎盘提取液可使高脂鼠血清中高密度脂蛋白明显升高 ,甘油三酯、胆固醇、低密度脂蛋白含量明显降低 (P <0 .0 1 ) ;使血浆中前列环素含量明显升高 (P <0 .0 1 ) ,Tx A2 含量无明显变化 ,并明显降低 MA(P <0 .0 1 )。结论 :胎盘提取液通过改善脂蛋白Objective:To study the effect of human placental extract (HPE) on lipoprotein cholesterol metabolism and platelet aggregation function in hyperlipemia rats.Method:Wistar mouse hyperlipemia model was established by given HPE 4 ml/(kg·d) through stomach for 12 days.Then the contents of their serum triglyceride (TG),cholesterol (CHO),low density lipoprotein (LDL C),high density lipoprotein (HDL C),and its subcomponent HDL 2 C;PGI 2,TxA 2 in plasma and maximum platelet aggregation rate(MA) were tested.Result:HPE increased the contents of HDL C,HDL 2 C PGI 2 (P< 0.01 ) and decreased the contents of TG,TC,LDL C (P< 0.01 ) in hyperlipemia rats.In addition,the PGI 2 level was increased (P< 0.01 )and MA was decreased (P< 0.01 ) in plasma.There was no changes about the contents of plasma TxA 2.Conclusion:HPE may ameliorate lipoprotein cholesterol metabolic disorder of hyperlipemia rats and inhibit platelet aggregation which may be beneficial to resist the occurrence and development of atherosclerosis.

关 键 词：入胎盘提取液 脂蛋白-胆固醇代谢 血小板聚集率 动脉粥样硬化 大鼠 

分 类 号：R543.505[医药卫生—心血管疾病]