顽固性心绞痛患者高位胸段硬膜外阻滞前后内皮素含量变化  

Changes of Endothelin-1 level during thoracic epidural anesthesia in patients with refractory angina pectoris

作　　者：陈国忠[1] 孙淑清[1] 李中言[1] 任旷[1] 李学[1] 曲仁海[2] 

机构地区：[1]吉林军医学院附属医院,132013 [2]哈尔滨医科大学第一临床医学院

出　　处：《上海医学》2001年第1期17-18,共2页Shanghai Medical Journal

摘　　要：目的　观察高位胸段硬膜外阻滞 (TEA)对顽固性心绞痛患者 (FAP)的治疗效果及其对内皮素(ET 1)的影响。方法　选择药物不能控制的心绞痛患者 2 0例接受TEA治疗。观察疗效并于TEA治疗前及TEA治疗后第 14天检测血浆ET 1的变化。结果　治疗后心绞痛缓解率 10 0 % ,心电图ST段压低导联数和ST压低值显著减少 (P <0 .0 5 ) ,血浆ET 1显著下降 (P <0 .0 1)。结论　TEA对顽固性心绞痛疗效满意 ,并可能与血浆ETObjective To investigate the changes of endothelin 1 (ET 1) level before and after thoracic epidural anesthesia (TEA) in patients with refractory angina pecrtoris. Methods Twenty patients with refractory angina pertoris received TEA, ET 1 was tested before and two weeks after TEA respectively.Results Pain relief was 100% after TEA. The extent of ST segment depression and ST depression in all leads decreased significantly after TEA ( P <0.05). Also, the level of ET 1 reduced significantly ( P <0.01).Conclusion TEA may be used as a therapeutic for patients with refractory angina pectris which may be due to fall of ET 1 level.

关 键 词：硬膜外阻滞 顽固性心绞痛 内皮素 TEA 

分 类 号：R541.4[医药卫生—心血管疾病]