冠心病患者同型半胱氨酸水平与血小板聚集功能的相关性探讨  

The Investigation of Homocysteine Levels and Platelet Aggregation in Patients with Coronary Heart Disease

作　　者：张云平[1] 王丽艳[1] 赵宇[1] 毕莉[1] 付璐[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院检验科,黑龙江哈尔滨150001

出　　处：《中国血液流变学杂志》2013年第3期535-537,共3页Chinese Journal of Hemorheology

基　　金：黑龙江省教育厅支持项目（11531203）

摘　　要：目的探讨冠心病患者同型半胱氨酸（Homocysteine,HCY）水平与血小板聚集功能之间的关系。方法检测112例冠心病患者及91名健康体检者的HCY水平及以二磷酸腺苷（ADP）和花生四烯酸（AA）为诱导剂的血小板聚集功能，进行统计对比分析。结果冠心病组的HCY水平、血小板聚集功能与对照组比较有显著差异（P〈0．05）；高HCY患者组的血小板聚集功能与正常HCY患者组比较有显著差异（P〈0．05）。结论HCY水平增高可引起血小板聚集功能增强，是冠心病反复发作的高危因素。Objective To investigate the relationship between homocysteine（HCY） levels and platelet aggregation in patients with coronary heart disease（CHD）.Methods 112 cases with CHD and 91 healthy controls were obtained for examining HCY and platelet aggregation induced by adenosine diphosphate（ADP） and arachidonic acid（AA）.Resuts HCY levels and platelet aggregation in CHD group were significantly higher than those of normal controls（P〈0.05）.Platelet aggregation were different between the CHD patients with hyperhomocysteine and the CHD patients with normal homocysteine（P〈0.05）.Conclusion Hyperhomocysteine may lead to the increase of platelet aggregation,which is one of the important risk reasons for recurrence of CHD.

关 键 词：冠心病 同型半胱氨酸 血小板聚集 

分 类 号：R541.4[医药卫生—心血管疾病] R446.11[医药卫生—内科学]