西格列汀致急性胰腺炎  

Acute pancreatitis after administration of sitagliptin

作　　者：赵培西 曹舫 王婧雯[2] 常瑛[2] 王磊[2] 乔逸[2] 文爱东[2] 

机构地区：[1]陕西省肿瘤医院药剂科,西安710061 [2]第四军医大学西京医院药剂科

出　　处：《药物不良反应杂志》2013年第6期350-351,共2页Adverse Drug Reactions Journal

摘　　要：1例58岁女性2型糖尿病患者应用盐酸二甲双胍(0.5 g,2次/d口服)及胰岛素(三餐前分别皮下注射胰岛素8、8、10 U,睡前皮下注射甘精胰岛素8 U)治疗,因效果不佳加用西格列汀(100 mg,1次/d口服)。3周后,患者出现恶心、呕吐伴腹痛。实验室检查:血清淀粉酶499 U/L,尿淀粉酶933 U/L。腹部超声检查示腹腔积液。诊断为急性胰腺炎。停用西格列汀、盐酸二甲双胍,继续应用胰岛素,并给予抑酸、抑酶、补液等治疗。6 d后,患者病情好转,血清淀粉酶76 U/L,尿淀粉酶288 U/L。A 58-year-old female patient with type 2 diabetes mellitus treated with metformin hydrochloride （0.5 g twice daily） and insulin （ subcutaneous of injection insulin 8,8,10 U before three meals respectively and subcutaneous injection of insulin glargine 8 U before sleep）. Sitagliptin 100 mg once daily was added to her regimen due to unsatisfactory efficacy. Three weeks later, the patients felt nausea, vomiting and abdominal pain. Laboratory examination showed a serum amylase value of 267 U/L and urine amylase value of 933 U/L. Abdominal uhrasonography revealed seroperitoneum. She was diagnosed as having acute pancreatitis. Sitagliptin and metformin hydrochloride were withdrawn and insulin was continued. Symptomatic treatment such as acid suppression, inhibition of digestive enzyme and fluid supplement were given. Six days later, the patient＇s condition improved, the levels of serum amylase and urine amylase were 76 U/L and 288 U/L, respectively.

关 键 词：西格列汀 二甲双胍 胰腺炎 

分 类 号：R595.3[医药卫生—内科学]