粒细胞-巨噬细胞集落刺激因子微球制剂治疗肿瘤的研究  

Therapy Effect of GM-CSF Microspheres on Tumor

作　　者：陈顺[1,2] 赵海平[1,2] 徐健雄[1,2] 郭秋圆[1,2] 黄袭雯[1,2] 陶安琪[1,2] 李晓鸣[1,2] 张向荣 林清[1] 

机构地区：[1]上海第十人民医院,上海200072 [2]上海交通大学药学院,上海200240 [3]深圳赛宝儿生物药业有限公司,广东深圳518129

出　　处：《现代生物医学进展》2013年第34期6623-6625,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81373366);医工交叉项目(YG2010ms11;YG2013MS62和YG2013MS52)

摘　　要：目的:评价粒细胞-巨噬细胞集落刺激因子(GM-CSF)微球剂型在肿瘤动物模型治疗作用。方法:建立肿瘤动物模型,微球剂型对该肿瘤模型治疗效果考察及毒性评价,同时与市售的注射水溶液剂型进行比较。结果:微球剂型和市售水溶液注射剂型同剂量对肿瘤模型治疗效果,微球剂型的效果明显好于市售的;同时微球剂型的毒性也小于市售的。结论:粒细胞-巨噬细胞集落刺激因子微球能提高GM-CSF治疗效果,同时降低毒性。Objective： To evaluate granulocyte - macrophage colony-stimulating factor （GM-CSF） microsphere formulations in ani- mal models of cancer treatment. Methods： The tumor animal model microsphere formulations investigated the therapeutic effect of tumor models and toxicity evaluation, while the commercially available injectable aqueous formulations were compared. Result： Compare the microsphere formulations and a commercially available injectable aqueous tumor model with treatment doses, the dosage form micro- spheres is obviously better than the commercially available; while microsphere formulations significantly was less than the toxicity of a commercially available. Conclusion： GM-CSF microspheres can improve the therapeutic effect of GM-CSF, while reducing toxicity.

关 键 词：GM—CSF 缓释微球 肿瘤 

分 类 号：Q813[生物学—生物工程] R94[医药卫生—药剂学]