不同剂量地佐辛用于腹腔镜妇科手术超前镇痛的效果观察  

Clinical Research on Preemptive Analgesia of Different doses of Dezocine on Patients Treated with Laparoscopic Gynecological Surgery

作　　者：叶红[1,2] 张云安[1] 崔敏[1] 吴进荣[1] 刘德胜[1] 

机构地区：[1]哈尔滨医科大学附属第一医院麻醉科,黑龙江哈尔滨150001 [2]大庆油田总医院,黑龙江大庆163000

出　　处：《现代生物医学进展》2013年第34期6757-6760,共4页Progress in Modern Biomedicine

摘　　要：目的：观察不同剂量地佐辛用于腹腔镜妇科手术超前镇痛的效果。方法：将90例ASAI．II级、年龄18~60岁拟行腹腔镜妇科手术的患者随机分成3组，每组30例，A组给予地佐辛0．1mg／kg开皮前15rain静脉注射；B组给予地佐辛0．15mg／kg开皮前15min静脉注射；C组给予地佐辛0．2mg／kg开皮前15min静脉注射，采用VAS评分评估术后镇痛效果并观察术后辅助镇痛药物的使用和不良反应的发生情况。结果：B、c组术后2、4、6、8h的VAS评分明显低于A组（P〈0．05）；C组术后2、4h的Ramsay评分明显高于A、B组（P〈0.05）；A组术后辅助镇痛药的使用率明显高于B组和C组（P／0．05）；3组不良反应的发生率比较均无统计学差异（P〉0．05）。结论：开皮前15rain静注地佐辛0．15mg／kg用于腹腔镜妇科手术镇痛效果好，且不增加不良反应的发生率。Objective： To observe the postoperative analgesia of different doses of dezocine in gynecological laparoscopic opera- tion. Methods： Ninety ASA I - II patients aged 20-60 years, undergoing the gynecological laparoscopic operation were randomly divided into three groups, 30 in each group. Patients in group A received dezocine 0.1mg/kg intravenous injection 15 minutes before skin inci- sion; patients in group B received dezocine 0.15mg/kg intravenous injection 15 minutes before skin incision; patients in group C received dezocine 0.2mg/kg intravenous injection 15 minutes before skin incision. The postoperative analgesic effects were estimated by Visual Analogue Scale （VAS）. Additional analgesics and adverse effects were recorded. Results： The VAS scores of group B and C were signifi- cantly lower than those of group A at 2h, 4h, 6h and 8h after surgery （P〈0.05）. The Ramsay scores of group A and B were significantly higher than those of group C at 2,4 h after surgery （P〈0.05）. The application rate of additional analgesics of group B and C were signifi- cantly lower than that of group A （P〈0.05）. No significant difference of the incidence of adverse effects was found among the three groups（P〉0.05）. Conclusion： 0.15mg/kg dezocine intravenous injection 15 minutes before skin incision could provide satisfying postoperative analgesia in patients undergoing gynecological laparoscopic operation and had lower incidence of adverse effects.

关 键 词：地佐辛 腹腔镜妇科手术 术后镇痛 

分 类 号：R614[医药卫生—麻醉学]