PI3-K/AkT信号转导通路与瘢痕形成研究进展  

The Researches Progress on the PI3-K/Akt Pathway and Scar Formation

作　　者：刘梦颖[1] 段晨阳[2] 张吉强[3] 

机构地区：[1]解放军第三军医大学学员旅二队,重庆400038 [2]解放军第三军医大学学员旅五队,重庆400038 [3]解放军第三军医大学神经生物教研室,重庆400038

出　　处：《现代生物医学进展》2013年第34期6790-6793,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(81171035)

摘　　要：临床上组织损伤2-3天后即可出现肉芽组织,进而由于成纤维细胞和血管内皮细胞的增殖逐渐形成纤维性瘢痕。瘢痕的形成与血管再生和细胞增殖及凋亡密切相关。常见的病理性瘢痕主要是增生性瘢痕和瘢痕疙瘩,他们不仅影响患者关键伤口的活动,而且在美观上给患者带来莫大的痛苦。但是由于对瘢痕的形成原因及发病机制仍不甚清楚,至今临床上实行地以手术为主的对瘢痕的治疗方法仍未取得较满意效果。磷脂酰肌醇3激酶(PI3K,phosphoinositide3-kinase)/Akt(PI3-k/Akt)通路广泛存在于人体的多个生理功能中,其在细胞因子作用下介导细胞生存已被证实,目前研究表明,PI3-k/Akt信号通路在瘢痕形成中也发挥了重要作用,这可能会为瘢痕的治疗带来新的前景。本文将就近年来关于PI3-k/Akt通路在中发挥的作用机制作一综述,并对未来利用此通路彻底治疗瘢痕的可能方式做一展望。Granulation tissues may form after tissues damage 2-3 days, and in turn, as the proliferation of fibroblasts and en- dothelial cells, fibrous scar will appear. The formation of scar is closely related to angiogenesis and cell proliferation or apoptosis. The common pathological scars are proliferative scar and keloid, they may cause movement disorders but are harmful to the appearance. Since the causes and pathological mechanisms of scar still stay unknown, no effective treatments have been put forward to eradicate scar clinically. PI3-K/Akt pathway is known to exist in many physiological functions, and it has been proved to involve in the survival of cells under stimulation of cytokines. It is reported that PI3-K/Akt pathway mediates the formation of scars, which may lead to a new prospect of the scars＇ therapy. This paper will review the roles that PI3-K/Akt plays in the formation of scar and comes up with new therapy of scar based on this pathway.

关 键 词：纤维性瘢痕 磷脂酰肌醇3激酶(P13K phosphoinositide3一kinase) Akt(P13·k Akt) 瘢痕形成 

分 类 号：Q75[生物学—分子生物学] R62[医药卫生—整形外科]