紫外线减毒血吸虫尾蚴免疫兔血清IgG水平动态及被动转移至小鼠诱导保护力研究  

DYNAMIC CHANGES OF IGG LEVELS AND PASSIVE TRANSFER OF RESISTANCE TO MICE WITH SERA FROM RABBIS VACCINATED WITH ULTRAVIOLET ATTENUATED CERCARIAE OF SCHISTOSOMA JAPOMICUM

作　　者：谢闻悦[1] 周晓红[2] 刘国章[2] 陈晓光[2] 李华[2] 郭春光[3] 

机构地区：[1]广州军区广州总医院,广州510010 [2]第一军医大学寄生虫学教研室 [3]第一军医大学南方医院康复科

出　　处：《中国人兽共患病杂志》2001年第1期42-44,共3页Chinese Journal of Zoonoses

基　　金：WHO/TDR资助

摘　　要：目的　本文用紫外线减毒日本血吸虫尾蚴多次免疫兔血清在不同时间被动转移至小鼠体内 ,并动态观察兔血清中的IgG抗体水平。 结果　显示血清在攻击感染前被动转移可激起小鼠较高的免疫保护力 (5 1% ) 。Aim Rabbits were vaccinated multiply with ultraviolet attenuated cercariae of Schistosoma japonicum,of which the levels of IgG antibody in serum were observed dynamically.At the same time,sera with vaccinated rabbits transfered passively to mice at different time to detect the resistant.The results showed attenuated rabbit sera confered significant levels of protection(51%) when transfered before challenge.This suggested that antibody might play an important role in the protective immunity elicited by uv attenuated Schistosoma japonicumcercariae mutiply.

关 键 词：日本血吸虫 紫外线减毒 IGG水平 保护力 小鼠 

分 类 号：R532.21[医药卫生—内科学] R454.2[医药卫生—临床医学]