新生儿缺血缺氧性脑病免疫功能检测的临床意义  

Clinical study on the changes of immune function in neonates with hypoxic-ischemic encephalopathy

作　　者：刘文彬[1] 郑砾[1] 邓琼仙[1] 孙先琳 吕洁[1] 

机构地区：[1]成都军区总医院儿科,四川成都610083

出　　处：《四川医学》2013年第10期1496-1497,共2页Sichuan Medical Journal

摘　　要：目的对新生儿缺血缺氧性脑病(HIE)免疫功能进行探讨,为其治疗提供理论依据。方法检测患儿的IL-6、IL-2、sIL-2R、T淋巴细胞亚群、免疫球蛋白和补体C3,分别采用双抗体夹心ELISA、APAAP、放射免疫扩散试验法进行。结果与对照组比较,HIE患儿的IgM和C3补体的浓度、CD3、CD4百分率、CD4/CD8比值和IL-2和IL-6水平明显降低(P均<0.01),而sIL-2R水平明显升高(P均<0.01)。结论 HIE患儿存在明显的体液和细胞免疫功能低下且紊乱,易继发感染。Objective To investigate the changes of immune function in neonates with hypoxic-ischemic encephalopathy （HIE）. Methods Fifty cases of HIE were collected to detect the immunoglobulin and complements in serum and T lymphocytes- ubsets,IL-2, slL-2R as well as IL-6 levels by radial immunodiffusion assay, APAAP and double antibody sandwith ELISA meth- ods. Results sIL-2R levels in patients with HIE were significantly higher （P 〈 0. 01 ）, while the levels of IgM, C3 and the pro- portion of CD4/CD8 ,the percentages of CD3and CD4 and IL-2 as well as IL-6 levels were significantly lower （P 〈 0. 01 ） than those in control group. Conclusions Immune function is low and disorder in neonates with HIE and this disorders in immune function have some effect in its pathogenisis.

关 键 词：新生儿 缺血缺氧性脑病 免疫功能 

分 类 号：R722.12[医药卫生—儿科]