盐酸妥洛特罗和班布特罗治疗儿童支气管哮喘的疗效和安全性比较  

Analysis of procaterol and bambuterol for treatment of asthmatic children

作　　者：方健 李勇[1] 赵君健 

机构地区：[1]南充市中心医院药剂科,四川南充637000

出　　处：《四川医学》2013年第10期1531-1533,共3页Sichuan Medical Journal

摘　　要：目的 对盐酸班布特罗片和盐酸妥洛特罗片治疗儿童支气管哮喘的安全性和有效性进行比较分析,为临床提供用药参考.方法 选取在某院就诊的3～9岁患儿92例,随机分成两个治疗组：妥洛特罗组和班布特罗组,分别给予妥洛特罗贴剂（阿米迪）和盐酸丙卡特罗口服液（帮备）,疗程均为2周.比较两组患儿咳嗽、胸闷、呼吸困难等日间症状、夜间症状和体征的改善率;比较两组患儿咳嗽、喘憋、喘鸣音的治疗时间,观察两组药物不良反应发生率.结果 妥洛特罗组缓解日间症状、夜间症状和体征的效果优于比较班布特罗组（P＜0.05）;妥洛特罗组和班布特罗组治疗哮喘的总有效率分别为71.8%和60.9%（P＜0.05）;两组咳嗽、喘憋、喘鸣音的平均消失时间差异无统计学意义（P〉0.05）.结论 与盐酸班布特罗口服液相比,妥洛特罗贴剂治疗儿童支气管哮喘临床疗效较好.Objective To observe the clinical efficiency and safety of Procaterol and Bambuterol in treatment of asthmatic children. Methods 92 asthmatic children were randomly divided into two groups ： Procaterol group （ n = 46 ） and Bambuterol group （ n = 46）. The courses was 2 weeks. The improve rate of daytime symptoms, nocturnal symptoms, the last time of cough, wheezing, breathlessness were compared. The adverse drug reactions were assessed as well. Results Procaterol had more significant efficien- cy in improve of daytime symptoms, nocturnal symptoms and signs （P 〈 0.05 ）. The last time of cough, breathlessness, and wheezing had no significant difference（ P 〉 0. 05 ）. The effective rates of Procaterol and Bambuterol were 71.8% and 60. 9% （P 〈 0. 05 ）. Conclusion Procaterol would be more effective and safer than Bambuterol in treatment of bronchial asthma.

关 键 词：盐酸班布特罗 盐酸妥洛特罗 支气管哮喘 

分 类 号：R725.6[医药卫生—儿科]