姜黄素及其制剂的药代动力学研究进展  

Progress in pharmacokinetics of curcumin and its dosage forms

作　　者：张彩云[1,2] 易加明 袁慧玲[1,2] 陈卫东[1,2] 鲁传华[1,2] 

机构地区：[1]安徽中医药大学,安徽合肥230031 [2]安徽省中药研究与开发重点实验室,安徽合肥230038

出　　处：《安徽医药》2014年第1期1-3,共3页Anhui Medical and Pharmaceutical Journal

基　　金：国家自然科学基金(No 51303006);安徽省教育厅自然科学项目(No KJ2012ZD09)

摘　　要：姜黄素具有多种药理作用,但结构和溶解性特点导致其在体内吸收差、代谢快、生物利用度低。剂型改造是解决姜黄素应用缺陷的有效方法之一,该文对近年来姜黄素剂型的药代动力学特点进行综述,发现姜黄素制剂能有效改善姜黄素生物利用度低的不足,并显示出较好的药代动力学特点。结合纳米技术将实现姜黄素制剂的多功能化,为姜黄素的临床应用提供更多理论依据和实验基础。Curculnin is extensively concerned and widely used in traditional Chinese medicine based on its several biological and pharlnacological activities,including anticancer, anti-imflalnlnatot7 and antioxidant properties. However,its poor aqueous solubility and instable structure lead to poor absorption,fast metabolism and low bioavailability ,which seriously hittder its therapeutic effeetivettess and clinical application. This review summarized pharmaeokinetie characteristics of eureumin and its six dosage forms in recent years. The result showed that several dosage forms of euremnin all effectively improve its drug concentration and bioavailability with other pharma- eokinetie parameter. Curemnin drug system combined with nanoteehnology can effectively improve the bioavailability ond fulfill multi- function,providing more theoretical and experimental basis for further clinical applieotion.

关 键 词：姜黄素 姜黄素制剂 药代动力学 生物利用度 

分 类 号：R285[医药卫生—中药学]