乌司他丁减轻血流感染患者全身炎性反应的临床观察  

Effect observation of ulinastatin on blood infection patients with systemic inflammatory response

作　　者：汪彦[1] 贾超[1] 

机构地区：[1]四川省绵阳市中心医院ICU,621000

出　　处：《临床合理用药杂志》2014年第2期11-12,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察乌司他丁对减轻血流感染患者全身炎性反应的临床疗效。方法选择重症监护病房(ICU)经病原学确诊为血流感染的患者27例,按随机原则分为试验组14例和对照组13例,2组给予相同的常规治疗,试验组在常规治疗的基础上加用乌司他丁。2组治疗时间均为7d。观察2组治疗前后急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分及C-反应蛋白(CRP)、降钙素原(PCT)水平。结果 2组治疗后APACHEⅡ评分、CRP、PCT水平较治疗前显著降低,且试验组低于对照组,差异有统计学意义(P<0.05)。结论乌司他丁能有效抑制血流感染患者的全身炎性反应,改善患者预后。Objective To observe the clinical effect of ulinastatin in treatment of patients with blood infection and its influence on systemic inflammatory response. Methods 27 cases in ICU with blood infection etiologically were randomly di- vided into trial group of 14 and control group of 13. Both groups received the same routine treatment,while the trial group ba- sing on the control group was added ulinastatin. Both groups had been treated for 7 days. Observed the effect of 2 groups. The a- cute physiology and chronic health evaluation II （ APACHE II ） score was estimated before and after the treatment in all the pa- tients,and their blood was tested for determination of C-reactive protein （CRP） and procalcitonin （PCT） levels. Results Compared with the indexes before treatment, all of them in the 2 groups were decreased significantly after treatment. Compared with the gontrol group,in the trial group, the APACHE II scores （ 13.9 ± 4.2 vs. 17.8 ±5.7 ）, CRP （ mg/L ： 9.8 ±2.6 vs. 13.4 ±3.1 ） ,PCT （ ng/m1：3.7± 1.8 vs. 8.5 ± 1.3） were declined more obviously, the differences were statistically significant （P 〈 0.05 ）. Conclusion Ulinastatin can down-regulate the degree of acute inflammatory response of patients with blood in- fection and improve their prognosis.

关 键 词：乌司他丁 血流感染 炎性反应 

分 类 号：R459.7[医药卫生—急诊医学]