N-杂环卡宾催化对硝基苯甲醛的氧化酯化  

N-Heterocyclic Carbene Catalyzed Oxidative Esterification of para-Nitrobenzaldehyde

作　　者：苏策[1] 夏淑娇[1] 王蕊[1] 

机构地区：[1]兰州理工大学石油化工学院,兰州730050

出　　处：《应用化学》2014年第2期165-170,116,共6页Chinese Journal of Applied Chemistry

基　　金：兰州理工大学优秀青年教师计划项目(Q200912)~~

摘　　要：以空气为氧化剂，研究了在N-杂环卡宾催化下，对硝基苯甲醛与9种醇的氧化酯化反应。 考察了不同卡宾前体、卡宾前体的用量以及溶剂对收率和反应速率的影响。 结果表明，当以对硝基苯甲醛摩尔分数10%的溴化3-乙基-4-甲基-5-羟乙基噻唑鎓盐为催化剂，过量的原料醇为溶剂时，可以有效地催化氧化对硝基苯甲醛进行酯化反应，收率为36%-64%，但当使用与对硝基苯甲醛等摩尔比的醇时，收率仅为9%-29%。Using air as the ultimate oxidant, a facile method for the oxidative esterification of para-nitrobenzaldehyde has been developed. The results demonstrated that the catalyst precursors, catalyst loadings and solvents have considerably effects on both the yields and reaction rates. A variety of para-nitrobenzonates were conveniently prepared with the yields of 36%-64% under the optimal reaction conditions, where the corresponding alcohols were used as the solvents, and the 3-ethyl-4-methyl-5-hydroxyethyl thiazole bromide salt as the catalyst precursor, with 10% molar fraction catalyst loading. Modest yields of 9%-29% were obtained if only stoichiometric amount alcohol was used.

关 键 词：N-杂环卡宾 对硝基苯甲醛 氧化酯化 对硝基苯甲酸酯 

分 类 号：O625[理学—有机化学]