酸脂清胶囊对实验大鼠急性痛风性关节炎模型IL-10和IL-1Ra的影响  

The influence of Suanzhiqing Capsules on IL-10 and IL-1Ra in Rats Model with Acute Gouty Arthritis

作　　者：朱金凤[1] 吴萍[1] 

机构地区：[1]青海大学医学院,西宁810010

出　　处：《世界中医药》2014年第1期78-80,共3页World Chinese Medicine

基　　金：2012年度青海大学医学院中青年教师科研基金团队项目(编号:2012-KYT-01)

摘　　要：目的:通过观察酸脂清胶囊的不同提取物对实验大鼠痛风性关节炎模型IL-10和IL-1Ra的影响,研究酸脂清胶囊的抗炎机制和对痛风性关节炎软骨破坏的影响,进一步指导临床用药。方法:酸脂清胶囊不同提取物(水提物,醇提物)给大鼠灌胃7d后,以尿酸钠晶体造成大鼠急性痛风性关节炎模型,分别在造模后9 h和12 h随机抽取8只大鼠测量踝关节直径,下腔静脉取血Elisa检测IL-10和IL-1Ra的量。结果:三个药物组的IL-10和IL-1Ra较模型组均有不同程度的升高,但水提组升高最为明显(P<0.05)。结论:酸脂清胶囊通过提高IL-10和IL-1Ra的水平,达到抗炎、保护关节软骨的作用,尤以水提组为优。Objective：To observe the effects of different extractions of Suanzhiqing capsules on rats with acute gouty arthritis .To study on the anti-inflammation mechanism and effect on cartilage damages in acute gouty arthritis rats .Methods：Water extractions and etha-nol extractions of Chinese medicines Suanzhiqing capsules were administrated intragastrically to the model rats .Seven days later , the rats were given uric acid sodium to cause acute gouty arthritis .And after 9 hours and 12 hours, eight rats were randomly selected each time in each group to measure the diameter of the ankle joint , and the contents of IL-1and IL-1Ra through Elisa method on the blood taken from inferior vena cava .Results：The level of IL-10 and IL-1Ra in the medicine groups were increased to some extent compared with the control group .The most significant increase was observed in the water extraction group .Conclusion：Suanzhiqing capsules can raise the level of IL-10 and IL-1 to cure inflammation and protect articular cartilage , especially with its water extraction group .

关 键 词：酸脂清胶囊 急性痛风性关节炎 IL-10 

分 类 号：R243[医药卫生—中医临床基础] R684.3[医药卫生—中医学]