暴发性1型糖尿病:一种不可忽视的重症糖尿病  

Fulminant Type 1 Diabetes Mellitus:Severe Diabetes Can Not Be Ignored

作　　者：时学秀 闫丹丹[1] 任彦红[1] 黄婷[1] 栗夏连[1] 

机构地区：[1]郑州大学第一附属医院内分泌科,河南郑州450052

出　　处：《医学与哲学（B）》2014年第1期63-65,共3页Medicine & Philosophy(B)

摘　　要：暴发性1型糖尿病以起病急骤、代谢紊乱严重、胰酶升高并缺乏糖尿病相关抗体为特征。本文回顾分析我院收治的3例暴发性1型糖尿病的临床资料并结合文献与经典1型糖尿病进行对比复习,以提高对该病的认识。3例患者平均病程5.3天,入院平均血糖27.8mmol/L,平均糖化血红蛋白(HbA1C)6.8%,平均空腹C肽0.043ng/ml,平均餐后2hC肽0.04ng/ml,平均胰岛素使用剂量0.50U/(kg·d)。随访6个月HbA1C平均值为7.5%,胰岛β细胞功能无改善。暴发性1型糖尿病较经典1型糖尿病有更严重的胰岛素缺乏、代谢紊乱,更强烈的免疫反应,预后较差。Fulminant type 1 diabetes is a subtype of type 1 diabetes characterized by a remarkably abrupt onset, severe metabolic disorders and often associated with elevated serum pancreatic enzymes, and absence of diabetes-related autoantibodies. Three cases of fulminant type 1 diabetes were reported retrospectively and analyzed with literatures review compared with classical type 1 diabetes. The mean duration was 5.3 days, the mean blood glucose level was 27.8mmol/L, the mean value of HbA1C was 6.77% the mean fasting serum C-peptide was 0. 043ng/ml, the mean serum postprandial C- peptid was 0.04ng/ml. The mean dose of insulin was 0.50U/（kg · d）, β-cell function did not recover after 6 months of follow- up. Fulminant type 1 diabetes shows more severe insulin deficiency, metabolic disorders, more intense immune response and even poor prognosis.

关 键 词：暴发性1型糖尿病 抗体 自身免疫性 

分 类 号：R587.1[医药卫生—内分泌]