辽宁省发热伴血小板减少综合征监测与病原学分析  

Epidemiology and etiology of severe fever with thrombocytopenia syndrome in Liaoning

作　　者：张洁[1] 刘芸[1] 王子江[1] 孙婷婷[1] 田疆[1] 毛玲玲[1] 孙英伟[1] 于丹梅[2] 吴炜[3] 李悦[4] 姚文清[1] 赵卓[1] 

机构地区：[1]辽宁省疾病预防控制中心,辽宁沈阳110005 [2]丹东市疾病预防控制中心 [3]大连市疾病预防控制中心 [4]抚顺市疾病预防控制中心

出　　处：《疾病监测》2013年第12期996-999,共4页Disease Surveillance

基　　金：国家科技重大专项(No.2012ZX10004-209);辽宁省科学技术计划项目(No.2013225079)~~

摘　　要：目的对2012年辽宁省发热伴血小板减少综合征(SFTS)流行病学特征和病原学检测结果进行分析,为临床诊断和预防控制提供依据。方法以实验室确诊SFTS患者为研究对象,描述三间分布、临床症状体征,并对分离到的病原进行核苷酸序列分析。结果 2012年辽宁省报告的185例疑似病例中,38例实验室确诊感染SFTSV,病死率为5.26%。病例多来自丘陵地区,以中老年、农民为主,无明显性别差异;发病时间为6—10月,部分病例发病前有明确的蜱叮咬史;临床表现主要为发热(100%)、头痛(73.68%)、恶心(65.76%);血常规检查有血小板计数减少(97.37%)和白细胞计数减少(78.95%)。分离到的9株SFTSV的S、M片段核苷酸序列同源性达95%以上。结论辽宁省是SFTS的流行地区,需提高SFTS的诊疗能力及加强对SFTS的预防控制。Objective To understand the epidemiological and etiological characteristics of severe fever with thrombocytopenia syndrome （SFFS） in Liaoning province in 2012 and provide evidence for the clinical diagnosis and prevention of SFTS. Methods The analysis was conducted on the distributions, clinical symptoms and etiological characteristics of laboratory confirmed SPTS cases in Liaoning during this period. Results Among 185 suspected SFTS cases reported, 38 were laboratory confirmed, the case fatality rate was 5.26%. Epidemiological findings revealed that most SFFS cases were distributed in farmers living in wooded and hilly areas and working in fields. SFTS, which had obvious seasonality, mainly occurred during June-October. Some cases had an obvious tick bite histories. The clinical manifestations included fever （100%）, headache （73.68%）, nausea （65.76%）, thrombocytopenia （97.37%） and leukocytopenia （78.95%）. The sequence homologies of segment S and M were up to 95% in 9 Bunyamwera virus strains isolated. Conclusion SFTS is endemic in Liaoning province. It is important to improve the diagnosis and treatment of SFTS and strengthen its prevention and control.

关 键 词：发热伴血小板减少综合征 布尼亚病毒 三间分布 序列分析 

分 类 号：R558.2[医药卫生—血液循环系统疾病]