磁性靶向顺铂白蛋白微球的研究  

Study on Magnetic Cisplatnum Albumin Microsphere for Lung Targeting

作　　者：邱广亮[1] 邱广明[2] 石晶瑜[1] 李咏兰[1] 韩毅强 

机构地区：[1]内蒙古师范大学生物系,内蒙古呼和浩特010022 [2]内蒙古工业大学电力学院动力系,内蒙古呼和浩特010022

出　　处：《广州化工》2000年第4期103-105,共3页GuangZhou Chemical Industry

基　　金：内蒙古教育厅高校研究资助!项目(A97044);内蒙古自然科学基金!项目(990303-3)

摘　　要：将顺铂和磁性氧化铁共包于白蛋白中而制成了磁性靶向顺铂白蛋白微球。按正交设计筛选最佳合成工艺为：顺铂用量为４０ｍｇ，白蛋白用量为２５０ｍｇ，ＦｅＣｌ２用量为２８２．８ｍｇ，ｐＨ＝１０。并以微球进行了质量考察：微球平均粒径为２．８９±０．５１μｍ，磁性靶向顺铂微球的载药量为１３．６４％（ｍｇ／ｍｇ），包裹率为８５．２４％；含药微球在体外１２ｈ释放完全，具一定的缓释作用；稳定性考察表明所制微球稳定性良好。Targeted and Magnetic cisplatnum albumin microspheres had been prepared by precipitation of magnetite from the mixture of ferrous ions and hydrogen peroxide in the presence of albumin and cisplatnum and sodium hydroxide. An optimum procedure was established by orthogonal test for preparing magnetic cisplatnum albumin microsphere: the mass concentration of albumin and ferrous chloride and cisplatnum were 250mg, 282. sing and 40mg respectively. pH value of solution was 10. The quality, stability, safety and drug loading were studied. The results showed that the mean size was 2. 89± 0. 51um, its embedding ratio was 85. 24%, its stability could be kept at 3-5℃ and room temperature for 3 months.

关 键 词：磁性靶向顺铂白蛋白微球 顺铂 肺癌 抗癌药物 

分 类 号：TQ462.8[化学工程—制药化工]