医药中间体溴代环丙烷合成新工艺的研究  

A New Synthetic Technique of Bromocy Clopropane

作　　者：张文楠[1] 李天仚[1] 崔惠芳[1] 朱靖[1] 

机构地区：[1]河南省科学院化学研究所,郑州450002

出　　处：《广州化工》2000年第4期106-107,共2页GuangZhou Chemical Industry

摘　　要：以ｒ－丁内酯为起始原料，通过改变工艺条件和选用相转移催化剂使新工艺三步即可合成出医药中间体溴代环丙烷，与原五步法合成工艺相比，不但缩短了工艺流程，易于工业化生产，而且使总收率由３２％提高到４５％。Using r - butyrolactone as the raw material, by selecting the optimum technical conditions and a phase transfer catalyst, The whole work was made up of three steps to synthesize bromocyclopropane. The overall yield was up from 35% to 45%. The reaction was easier to control and the cost was lower. This new method is more suitable for the industrial production.

关 键 词：Γ-丁内酯 溴代环丙烷 相转移催化剂 药物中间体 

分 类 号：TQ463.3[化学工程—制药化工]