脑外伤后继发性损伤研究现状  

Secondary injury after brain trauma

作　　者：高峰[1,2] 闫玉仙[3] 毕海涛[1] 刘霞[1] 

机构地区：[1]河北医科大学法医系,河北石家庄050017 [2]河北省公安厅物证鉴定中心,河北石家庄050017 [3]武警后勤学院,天津300309

出　　处：《武警后勤学院学报（医学版）》2013年第12期1120-1122,共3页Journal of Logistics University of PAP（Medical Sciences）

摘　　要：近年来人们对脑外伤后继发性损伤的研究越来越深入,继发性损伤主要表现为脑水肿、脑肿胀、脑微循环障碍等。这是一个非常复杂的生物化学过程,各种损伤途径彼此间错综联系、相互影响,共同发挥作用。通过研究发现,脑外伤后微循环改变、氧自由基产生、神经递质释放、炎症因子损伤等途径在继发性损伤中起重要作用。对它们的研究可进一步揭示颅脑外伤的病理发展过程,对诊断治疗也有参考作用。In recent years, more and more researches have been done in secondary injury after brain trauma, secondary injury showed mainly cerebral edema, progressive intracranial hypertension , cerebral contusion , ischemia and hypoxia, acidosis. This is a very complex biochemical process, various factors are not to bring into play singly, but to interact one another. From the study, we found that oxygen free radicals, neurotransmitters and inflammatory cytokines play important role in secondary injury. The research on secondary injury can reveal the pathological process of occurrence and development, which seem to be able used for the diagnosis and treatment.

关 键 词：脑创伤 继发性损伤 氧自由基 神经递质 炎症因子 

分 类 号：R651[医药卫生—外科学]