高同型半胱氨酸血症对脑小血管病所致认知功能障碍的影响  

Influence of hyperhomocysteinemia levels on cognitive dysfunction of cerebral small vascular disease

作　　者：于怀成 石小晶[1] 刘媛媛 李霜梅[1] 张春荣[1] 杨文军[1] 王帅[1] 苏宏图 马丽书[1] 兰希发[1] 

机构地区：[1]河北省秦皇岛市海港医院神经内科,066000 [2]秦皇岛市公安医院内科

出　　处：《神经疾病与精神卫生》2013年第6期610-612,共3页Journal of Neuroscience and Mental Health

摘　　要：目的 探讨高同型半胱氨酸血症对脑小血管病所致的认知功能障碍的影响.方法 选取符合脑小血管病诊断标准的病例,进行MoCA评分,分为有认知功能障碍组及无认知功能障碍组,测定同型半胱氨酸的水平,观察两组之间同型半胱氨酸水平的差异,并对不同认知功能受损方面进行评定.结果 有认知功能障碍组明显高于无认知功能障碍组,两组间差异有统计学意义（P＜0.01）.认知功能障碍患者中在语言、视空间及执行功能上有障碍患者的Hyc水平高于无相应障碍者,Hyc水平差异有统计学意义（P＜0.05）.结论 高同型半胱氨酸血症是脑小血管病所致认知功能障碍的影响因素之一,而且对执行功能、视空间功能、语言功能的影响更明显.Objective To study the influence of hyperhomocysteinemia levels on cognitive dysfunction of cerebral small vascular disease. Methods Cases of cerebral small vascular disease diagnosis standard of MoCA score were selected, divided into Cognitive Dysfunction Group and Non-- cognitive Dysfunction Group, determined levels of homocysteine, observed the differences of homocysteine level between two groups and assessed the level of cognitive function. Results Homocysteine level of cognitive dysfunction group was significantly higher than that of non--cognitive dysfunction group; in cognitive dysfunction group, impaired executive function, visual space function, language of homocysteine levels were significantly higher than those without damaged. Conclusions H yperhomocysteinemia level, is one of the factors which cause the small brain vascular disease and cognitive dysfunction, and has more obvious influence on the executive, visual space and language functions.

关 键 词：高同型半胱氨酸血症 脑小血管病 认知功能障碍 执行功能 视空间功能 

分 类 号：R589.3[医药卫生—内分泌]