持续非卧床腹膜透析患者低T3综合征与大动脉僵硬度的关系  

Association betw een low T3 syndrome and arterial stiffness in continuous ambulatory peritoneal dialysis patients

作　　者：梁素忍[1] 郭志玲[1] 胡昭[2] 

机构地区：[1]河南科技大学第一附属医院肾内科,河南洛阳471000 [2]山东大学齐鲁医院肾内科,济南250012

出　　处：《山东大学学报（医学版）》2014年第1期67-70,共4页Journal of Shandong University:Health Sciences

基　　金：国家科技支撑计划(2007BAI04B10)

摘　　要：目的探讨持续非卧床腹膜透析(CAPD)患者低T3综合征与大动脉僵硬度的关系。方法采用横断面研究,选取129例CAPD患者为研究对象。根据甲状腺功能分为低T3综合征组和甲状腺功能正常组。常规标准测量甲状腺功能和其他生化指标,自动PWV分析仪检测颈-股动脉脉搏波传导速度(C-F PWV),以评估大动脉僵硬度。结果低T3综合征患者与甲状腺功能正常组相比年龄偏大(P<0.001),女性患者比例偏大(P=0.044),脉搏波传导速度明显增快(P<0.001)。PWV与糖尿病(P<0.001)、年龄(P=0.001)、收缩压(P=0.038)、舒张压(P=0.045)、甲状腺功能(P<0.001)、血浆白蛋白(P=0.007)、KT/V(残肾)(P=0.018)呈统计学相关。多元回归分析结果显示,游离三碘甲状腺原氨酸(FT3)、糖尿病状态、年龄是PWV变化的独立危险因素。结论 CAPD患者低T3综合征与脉搏波传导速度密切相关,即慢性腹膜透析合并低T3综合征患者大动脉僵硬度增加。Objective To investigate the association between low I3 syndrome and arterial stiffness in continuous ambulatory peritoneal dialysis （CAPD） patients. Methods 129 CAPD patients were divided into the low T3 syndrome group and euthyroid function group. All patients received a series of examinations every 3 months, including blood biochemical indices and pulse wave velocity （PWV）for arterial stiffness. The data were analyzed using an independent t-test to compare PWV, blood biochemical indices and metabolic status between low T3 syndrome and euthyroid patients. Multiple regression analysis was performed to identify risk factors for PWV. Results Both age and proportion of female patients were significantly higher in low T3 syndrome group compared with the euthyroid function group （ P 〈 0. 001 ; P = 0. 044 ）, although no significant differences in hemoglobin, albumin, metabolic status or other values were found. However, PWV was much higher in low T3 syndrome group than that in euthyroid function group （P 〈 0.001 ）. PWV was significently correlated with the diabetes （ P 〈 0. 001 ）, age （ P = 0. 001 ）, systolic pressure （ P = 0. 038 ）, diastolic pressure （ P = 0.045 ）, euthyroid function （ P 〈 0. 001 ）, plasma albumin （ P = 0.007 ） and KT/V （ remnant renal function） （P = 0.018 ）. Multiple regression analysis revealed that the level of free triiodothyronine （FF3）, diabetic status and age were the independent risk factors of PWV. They accounted for 57.0% of the total variance. Conclusion The CAPD with low T3 syndrome is correlated with PWV, and the CAPD patients with low T3 syndrome show increased arterial stiffness.

关 键 词：低T3综合征 大动脉僵硬度 脉搏波传导速度 腹膜透析 

分 类 号：R459.5[医药卫生—治疗学]