Serum interleukin-10 levels and adverse events in patients with acute coronary syndrome： a systematic review and meta-analysis  

作　　者：Liu Jun Jia Yanjun Li Xiaolin Xu Ruixia Zhu Chenggang Guo Yuanlin Wu Naqiong Li Jianjun 

机构地区：[1]Division of Dyslipidemia, Cardiovascular Medicine, Fu Wai Hospital,State Key Laboratory of Cardiovascular Disease, National Centerfor Cardiovascular Diseases, Chinese Academy of Medical Sciences,Peking Union Medical College, Beijing 100037, China

出　　处：《Chinese Medical Journal》2014年第1期150-156,共7页中华医学杂志（英文版）

基　　金：This work was partially supported by the National Science Foundation of China （NSFC, No. 81070171） awarded to Dr. Li Jianjun.

摘　　要：Background Several studies investigating the prognostic utility of interleukin-10 （IL-10） in patients with acute coronary syndrome （ACS） have provided conflicting findings.The aim of the study was to assess the existing evidence regarding association between serum IL-10 levels and adverse events.Methods Literature search was performed in PubMed,EMBASE,and Cochrane Trials Register databases from their inception to September 30,2012.In addition,reference lists of the included articles and their related citations in PubMed were also reviewed for additional pertinent studies.Results A total of 12 eligible studies comprising a total of 5882 patients were identified.The pooled relative risks for both studies reporting the risk estimates by IL-10 categories and studies reporting the risk estimates by unit IL-10 indicated an association between high IL-10 levels and adverse events.Sensitivity and subgroup analysis indicated that the results obtained in IL-10 categories were not stable.Conclusions Data from our meta-analysis supported the existence of a relationship between high serum IL-10 levels and adverse events in patients with ACS.Large study with longer follow-up is needed to confirm the findings.Background Several studies investigating the prognostic utility of interleukin-10 （IL-10） in patients with acute coronary syndrome （ACS） have provided conflicting findings.The aim of the study was to assess the existing evidence regarding association between serum IL-10 levels and adverse events.Methods Literature search was performed in PubMed,EMBASE,and Cochrane Trials Register databases from their inception to September 30,2012.In addition,reference lists of the included articles and their related citations in PubMed were also reviewed for additional pertinent studies.Results A total of 12 eligible studies comprising a total of 5882 patients were identified.The pooled relative risks for both studies reporting the risk estimates by IL-10 categories and studies reporting the risk estimates by unit IL-10 indicated an association between high IL-10 levels and adverse events.Sensitivity and subgroup analysis indicated that the results obtained in IL-10 categories were not stable.Conclusions Data from our meta-analysis supported the existence of a relationship between high serum IL-10 levels and adverse events in patients with ACS.Large study with longer follow-up is needed to confirm the findings.

关 键 词：INTERLEUKINS acute coronary syndrome cardiovascular event META-ANALYSIS 

分 类 号：Q51[生物学—生物化学] S828[农业科学—畜牧学]