2012年儿童药物浓度监测分析  

Analysis of therapeutic drug monitoring on Children in 2012

作　　者：祁俊华 何艳玲 和凡 杨彤 

机构地区：[1]广州市妇女儿童医疗中心,510120

出　　处：《广州医药》2014年第1期14-17,共4页Guangzhou Medical Journal

基　　金：广东省医院药学研究基金(2011A13);广州市医药卫生科技项目(201102A213030)

摘　　要：目的对本院2012年儿童血药浓度监测结果进行回顾性分析,为临床合理用药提供依据。方法采用酶增强免疫分析法(EMIT)测定,对服用丙戊酸钠、苯妥英、卡马西平、地高辛、茶碱、甲氨蝶呤、环孢素、他克莫司的病人进行血药浓度监测,并对4055例监测结果进行统计和分析。结果丙戊酸钠的受检例数最多,2679例(75.89%),平均浓度(58.70±25.97)μg/ml,地高辛的受检例数最少,只有2例。三个免疫抑制剂项目中,甲氨蝶呤的受检例数最多,463例(31.1%)。结论血药浓度监测对指导儿童临床合理用药具有重要作用。Objective To retrospective analyze the therapeutic drag monitoring results on ehihh＇en in 2012. Methods Concentrations of Valproie acid, phenytoin, earbamazepine, digoxin, theophylline, MTX, eyelosporin and aernlimus in serum or blood of 4055 chihlren were detected by EMIT （enzyme-muhiptied immunoassay technique） , and these resuhs were statisti- eally analyzed. Results Cases of valproie acid had the most tests, accounted for 75.89% （2679 tests） , and the average concentration was （58.70 ±25.97）μg/ml, and eases of digoxin had the least tests-- only 2 tests. During the three immtmo- suppressive agents sub ieets, MTX had the most tests, accounted for 31. 1% （463 tests）. Conclusion The therapeutic drug monitoring has important signifieanee for rational use of drug, and needed further improvement in clinical application.

关 键 词：药物浓度 酶增强免疫分析法 儿童 

分 类 号：R96[医药卫生—药理学]