山大颜Psychotria sp.中皂苷类化合物研究  

Saponins from the Stem of Psychotria sp.

作　　者：叶会呈[1] 郑晓辉[2] 汪玉梅[1] 彭光天[1] 苏贤君 雷玲芳[1] 张翠仙[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006 [2]广州中医药大学第一附属医院药学部,广东广州510405

出　　处：《中山大学学报（自然科学版）》2014年第1期93-97,共5页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：广东省科技计划重点资助项目(2010A03010003);广东省分析测试技术公共实验室开放课题资助项目(001)

摘　　要：继续对山大颜具有抗肿瘤活性的乙酸乙酯部分进行活性成分分离,得到4个三萜及其苷类化合物。采用物理常数对照和现代波谱分析技术及化学方法对其结构进行研究,确定其为:Psychotrianosides G(1)、Ardisianosides D(2)、β-香树脂醇(3)、豆甾醇-3-O-β-D-葡萄糖苷(4)。将化合物2水解得到Cyclamiretin A(5)。化合物1为首次得到的天然产物,首次采用2D NMR技术对其NMR数据进行全归属。所有化合物均首次从九节属中得到。To continue to study anti-tumour bioactive saponins EtOAc layer from methanol extract of the stem of psychotria sp. , four compounds were obtained by all kinds of column chromatography, such as silica gel, Sephdex LH -20, and ODS. Their structures were characterized by spectroscopy including NMR, MS, GC-MS analyses, and chemical and the physical methods. The result indicated that they were Psychotrianosides G （1）, Ardisianosides D （2）, fl-amyrin （3）, and Stigmasterol-3-O-β-D-glycosidase （4）. Cyclamiretin A （5） was obtained by acid hydrolysis of 2. Psychotrianosides G （1） was firstly obtained as a natural product. The chemical structure of compound （1） was analyzed by 2D NMR firstly. Compounds 1, 2, 3, 4, 5 were firstly obtained from genus of psychotria.

关 键 词：PSYCHOTRIA SP 化学成分 三萜皂苷 结构分析 

分 类 号：R284.2[医药卫生—中药学] O629.7[医药卫生—中医学]