哌拉西林/他唑巴坦治疗早产儿院内细菌感染疗效观察  

Clinical Efficacy of Piperacillin/Tazobactam in Preterm Neonates with Nosocomial Bacterial Infection

作　　者：王冬娥[1] 

机构地区：[1]浙江省宁波市妇女儿童医院,浙江宁波315000

出　　处：《儿科药学杂志》2014年第2期12-14,共3页Journal of Pediatric Pharmacy

摘　　要：目的:观察哌拉西林/他唑巴坦治疗早产儿院内细菌感染的疗效。方法:回顾性分析哌拉西林/他唑巴坦治疗87例早产儿院内细菌感染的临床疗效和不良反应。结果:87例院内细菌感染早产儿应用哌拉西林/他唑巴坦治疗后,痊愈61例,显效18例,进步6例,无效2例,治疗有效率90.80%;其中6例治疗进步患儿经加用静脉丙种球蛋白治疗后痊愈,2例治疗无效患儿改用其他抗生素治疗;发生不良反应2例(2.29%),其中1例出现少许皮疹,1例出现尿蛋白轻微增高,停药后均自行消失。结论:哌拉西林/他唑巴坦治疗早产儿院内细菌感染安全有效,对难治性、院内重症感染可加用静脉丙种球蛋白联合治疗,效果更佳。Objective： To evaluate the effect and safety of Piperacillin/tazobactam in treating nosocomial bacterial infection in preterm neonates. Methods： Clinical efficiency and side effects of Piperacillin/tazobaetam on nosocomial bacterial infection in eighty-seven preterm neonates were retrospectively analyzed. The evaluation of clinical effect was divided into four degrees： healing, excellent, improvement and invalidation. The degrees of healing and excellent were considered as effective. Results： After the treatment, the cases of healing, excellent, improvement and invalidation were sixty-one, eighteen, six and two respectively; the total curative effect rate was 90.80%. The improvement and invalidation cases treated with gammaglobulin additionally were healing eventually. Two cases （2.29%） developed side effects： one case had skin rash, and one had abnormal urinary protein. The side effects were slight and disappeared after the stop of drugs. Conclusions： Piperacillin/tazobactam is a safe and effective drug for the treatment of nosocomial bacterial infection in preterm neonates.

关 键 词：哌拉西林 他唑巴坦 早产儿 院内感染 

分 类 号：R978.1[医药卫生—药品]