双夏汤不同洗脱液镇静催眠作用研究  

Study on Sedative and Hypnotic Effects of Different Eluents of Shuangxiatang

作　　者：裴文慧 孙毅坤[1] 张俊义[1] 王冉[1] 段娟娟[1] 何爱先 邹桂林 方芳[1] 

机构地区：[1]北京中医药大学中药学院/中药基础与新药研究北京市重点实验室,北京100102

出　　处：《世界科学技术-中医药现代化》2013年第8期1713-1716,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委面上项目(81173521):基于受体学说双夏汤治疗失眠的物质基础及作用机制研究;负责人:孙毅坤

摘　　要：目的:研究双夏汤不同洗脱液的镇静催眠作用。方法:通过测定小鼠自主活动和对戊巴比妥钠阈下剂量诱导睡眠的作用,观察双夏汤水煎液、水洗液、20%、70%和95%醇洗液的镇静催眠作用。结果:双夏汤水煎液、20%和95%醇洗液显著降低小鼠的站立次数,分别为78.5%,78.3%和62.5%;双夏汤水洗液和70%醇洗液能显著降低小鼠自主活动次数(P<0.01)、站立次数(P<0.01)和修饰时间(P<0.05)。双夏汤水煎液能明显缩短小鼠睡眠的潜伏期(P<0.05),延长小鼠睡眠时间(P<0.05),增加小鼠的入睡率。双夏汤水洗液能显著缩短小鼠睡眠潜伏期(P<0.05),增加小鼠的入睡率。结论:双夏汤水煎液和水洗液的镇静催眠作用优于醇洗液。This article was aimed to study the sedative and hypnotic effects of different eluents of Shuangxiatang （SXT）. The effects of SXT water decoction, water eluent, 20%, 70% and 95% alcohol eluent on spontaneous ac-tivity and the sleeping induced by subthreshold dose of pentobarbital sodium were measured. The results showed that the SXT decoction, 20% and 95% alcohol eluent can significantly decrease the number of rearing in mice with the percentage of 78.5%, 78.3% and 62.5%, respectively. SXT water eluent and 70% alcohol eluent can significantly decrease the spontaneous activity of mice （P 〈 0.01）, the number of rearing （P 〈 0.01） and grooming time （P 〈 0.05）. SXT water decoction can significantly shorten sleep latency （P 〈 0.05）, prolong sleep time （P 〈0.05）, and increase rates of sleeping in mice. SXT water eluent can significantly shorten sleep latency in mice （P〈 0.05）, increase rates of sleeping in mice. SXT water decoction and water eluent have the sedative and hypnotic effects. And the effects are more than alcohol eluents.

关 键 词：双夏汤 洗脱液 自主活动 镇静催眠 

分 类 号：R285.5[医药卫生—中药学]