不同工艺疏血通脉胶囊对小鼠凝血功能及血栓形成的影响  

Effects of Different Production Techniques of Shuxue Tongmai Capsules on Mouse Blood Coagulation Function and Thrombosis Formation

作　　者：刘泰[1] 周军[2] 林秋红[1] 胡玉英[1] 曹斌[2] 高微[2] 吴玉强[2] 王丽[2] 刘瑛[2] 张青萍[1] 何乾超[1] 

机构地区：[1] 广西中医药大学第一附属医院 南宁 530023 [2] 广西中医药研究院 南宁 530023

出　　处：《世界科学技术-中医药现代化》2013年第8期1792-1795,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：广西省科技厅自然基金项目(2011GXNSFA018180):疏血通脉胶囊预处理对脑缺血大鼠MAPKs通路的影响研究,负责人:刘泰;广西省科技厅科技攻关课题(桂科攻11107009-1-11):缺血性中风新药-疏血通脉胶囊的临床前研究,负责人:刘泰

摘　　要：目的:观察不同工艺疏血通脉胶囊对小鼠凝血功能及血栓形成的影响。方法:观察不同工艺疏血通脉胶囊对小鼠的凝血时间、出血时间的影响和对胶原蛋白-肾上腺素小鼠血栓模型的保护作用。结果:与Ⅱ号、Ⅲ号工艺的疏血通脉各剂量组比较,Ⅰ号工艺疏血通脉等剂量组能显著延长小鼠凝血时间(P<0.05),显著提高胶原蛋白-肾上腺素血栓模型小鼠的存活恢复率(P<0.05);Ⅰ号工艺疏血通脉等剂量组对小鼠出血时间影响无显著差异。结论:疏血通脉胶囊具有抑制凝血及抗血栓形成的作用,其中以Ⅰ号工艺疏血通脉胶囊的效果较好。This study was aimed to evaluate effects of different production techniques of Shuxue Tongmai （SXTM） capsules for blood coagulation function and thrombosis formation among mice. The observation was made on the clot-ting time, bleeding time and instauration rate of collagen-adrenaline model of mice. The results showed that com-pared with SXTM II and Ⅲ production technique, the SXTM I production technique of the same dosage group can prolong the clotting time of mice significantly （P 〈 0.05）, and increase the instauration rate of collagen-adrenaline model of mice significantly （P〈 0.05）. There was no significant difference on the bleeding time of mice between the SXTM I production technique of same dosage group and the saline group. It was concluded that the SXTM had an-ticoagulative and antithrombotic effects. And the SXTM I production technique receives better effects.

关 键 词：疏血通脉胶囊 凝血时间 出血时间 胶原蛋白-肾上腺素小鼠血栓模型 

分 类 号：R285.5[医药卫生—中药学]