不同型号大孔树脂吸附青风藤中青藤碱特性的研究  

Research on Absorption of Sinomenine in Caulis Sinomenii by Different Types of Macroporous Resin

作　　者：吴建雄[1] 秦建平[1] 曹光环[1] 刘启安[1] 王振中[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司/中药制药过程新技术国家重点实验室/江苏省企业院士工作站,连云港222001

出　　处：《世界科学技术-中医药现代化》2013年第9期1971-1974,共4页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家重大新药创制项目(2011ZX09401-014):中药治疗心脑血管疾病有效成分组(群)的创新药物孵化基地--注射用QHMT临床前研究;总课题负责人:江希明;子课题负责人:孙永成

摘　　要：目的:研究不同型号大孔树脂对青风藤中青藤碱的吸附效果。方法:以青藤碱转移率为考察指标,对大孔树脂吸附纯化青风藤生物碱的工艺进行筛选。结果:pH2条件下AL-3树脂对青藤碱吸附和解析效果最好,pH6条件下X-5树脂吸附和解析效果最好。结论:筛选树脂应综合考虑目标化合物的性质和树脂的孔径、比表面积、极性等参数。This article was aimed to study the absorption of sinomenine in Caulis Sinomenii by different types of macroporous resin. The transfer rate of sinomenine was used as detection index. The screening was made on the technological process of absorption and purification ＇of sinomenine by macroporous resin. The results showed that the macroporous resin AL-3 was selected with the best absorptive capacity under pH2, while the macroporous resin X-5 was selected with the best absorptive capacity under pH6. It was concluded that the selection of macroporous resin should comprehensively consider the properties of target compounds, and indexes such as aperture, specific surface area, and polarity of maeroporous resin.

关 键 词：大孔树脂 青风藤 青藤碱 吸附 

分 类 号：R284[医药卫生—中药学]