芍药苷-6-O'-苯磺酸酯理化性质研究  

Study on paeoniflorin-6'O-benzene sulfonate's physicochemical property

作　　者：王春[1] 袁君[1] 魏伟[1] 

机构地区：[1]安徽医科大学临床药理研究所,抗炎免疫药物教育部重点实验室,合肥230032

出　　处：《安徽医科大学学报》2014年第2期202-205,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:81330081;81302845;81173075)

摘　　要：目的考察芍药苷-6-O'-苯磺酸酯(代号CP-25)的理化性质。方法 CP-25理化性质以外观性状、Lieberman-Burchard反应、薄层色谱图、紫外吸收光谱、溶解度和稳定性进行评价;CP-25含量采用高效液相色谱法进行测定。结果CP-25具有萜类化合物特征颜色反应;其最大紫外吸收波长为220 nm;CP-25在水和石油醚中均微溶;影响其稳定性的主要因素是湿度。结论当前考察的CP-25理化性质为其质量标准制定和制剂设计提供一定实验依据。Objective To investigate the physicochemical property of Pae-6’O-benzene sulfonate （ CP-25 ） . Meth-ods The CP-25 physicochemical property was evaluated by appearance, Lieberman-Burchard reaction, thin-layer chromatogram, Ultraviolet Spectrophotometry （ UV） , solubility and stability. The content of CP-25 was assayed by high performance liquid chromatography. Results The CP-25 had color response featured by terpenoid, and its maximum UV absorption wavelength was 220 nm. CP-25 was slightly soluble in water and petroleum ether. The main influence factor of CP-25 stability was humidity. Conclusion The present study provides experimental basis for quality standard and formulation design of CP-25 .

关 键 词：芍药苷-6-O'-苯磺酸酯 理化性质 薄层色谱 高效液相色谱法 

分 类 号：R917[医药卫生—药物分析学] R927[医药卫生—药学]