MRS对脑星形细胞瘤周围组织的应用价值  

Application value of MR spectroscopy in the peritumoral tissue of brain astrocytic tumours

作　　者：林祺[1] 何永红[1] 唐平太[1] 汤琅琅[1] 

机构地区：[1]福建医科大学附属龙岩第一医院放射科,龙岩364000

出　　处：《磁共振成像》2014年第1期11-14,共4页Chinese Journal of Magnetic Resonance Imaging

基　　金：福建省医学创新课题基金(编号:2011-CXB-28)

摘　　要：目的应用3.0 T多体素氢质子磁共振波谱(1H-MRS)探讨不同级别脑星形细胞瘤周围组织代谢物的表现,评价MRS定量比值在星形细胞瘤周围组织的应用价值。方法 82例经病理组织学证实脑星形细胞瘤1H-MRS影像学资料,分为低级别组(WHO I^II)32例和高级别组(WHO III^IV级)50例,分别测量瘤体实质区、周围组织区及对侧正常区代谢物的半定量和相对定量比值,以界值取P<0.05。结果 1H-MRS显示高级别星形细胞瘤与低级别星形细胞瘤周围组织的Cho/Cr和Cho/NAA相对定量比值差异有统计学意义(P值均<0.01),NAA/Cr值差异无统计意义(P>0.05)。结论脑星形细胞瘤周围组织代谢物MRS定量比值变化反映了不同级别肿瘤生物行为,对确定脑星形细胞瘤的分级及显示侵袭的范围有重要临床实用价值。Objective： To discuss metabolic feature in the peritumoral tissue of different ranks brain astrocytic tumours with multi-voxel proton magnetic resonance spectroscopy （1H-MRS）, and estimate its application value on of brain astrocytic tumours. Materials and Methods：82 patients with brain astrocytic tumours conifrmed by postoperative pathologic were collected, which were divided into low grade astrocytic tumours （WHO I-II） 32 cases, and high grade astrocytic tumours （WHO III-IV） 50 cases. The semiquantitative and relatively quantitative ratio of metabolic of the parenchyma area,peritumoral tissues area,and area with normal area were measured, and value was set as P＆lt;0.05. Results：The relative quantitative ratios of Cho/Cr, Cho/NAA significantly differed in peritumoral tissues area of the high grade astrocytic tumours and the low grade astrocytic tumours （P＆lt;0.01）, but NAA/Cr had no signiifcant difference （P＆gt;0.05）. Conclusions： The changes of the MRS quantitative ratio in brain astrocytic tumours peritumoral tissues area relfects the level of different tumor biological behavior, and it has important clinical value in determining the classiifcation of the brain astrocytic tumours and the scope of attack.

关 键 词：星形细胞瘤 脑肿瘤 磁共振波谱学 

分 类 号：R445.2[医药卫生—影像医学与核医学] R730[医药卫生—诊断学]