新型多甲氧基取代二苯醚类化合物的合成  

Synthesis of Novel Polymethoxy Diphenyl Ethers

作　　者：刘伏[1] 张学胜[1] 王遵尧[1] 

机构地区：[1]南京大学环境学院污染控制和资源化国家重点实验室,江苏南京210023

出　　处：《合成化学》2014年第1期6-11,共6页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(41071319,20977046);中央高校基本科研业务基金资助项目(1112021101)

摘　　要：以碘化亚铜为催化剂,Cs2CO3为碱,甲氧基取代苯酚（1）和甲氧基取代碘苯通过偶联反应形成C-O-C键,合成了27个新型的多甲氧基取代二苯醚类化合物,其结构经1H NMR和IR表征。最佳合成条件为：1 1.0mmol,CuI 0.10 mmol,Cs2CO32.0 mmol,DMF为溶剂,N2保护下于130℃下回流反应16 h。在最佳反应条件下,收率37%~94%。Twenty seven novel polymethoxy diphenyl ethers were synthesized by coupling reaction of methoxy-iodobenzenes and methoxy-phenols（ 1） using CuI as the catalyst,cesium carbonate as the base. The structures were characterized by1H NMR and IR. The optimum reaction conditions at 130 ℃ for 16 h under N2 atmosphere were as follows： 1 was 1. 0 mmol,CuI was 0. 10 mmol,Cs2CO3 was 2. 0 mmol,DMF was the solvent. The yield were 37% ~ 94% under the optimum reaction conditions.

关 键 词：甲氧基取代苯酚 甲氧基取代碘苯 多甲氧基取代二苯醚 合成 

分 类 号：O625.32[理学—有机化学]