AT1R基因A1166C多态性与新疆维吾尔族人群原发性高血压的关系  

Association between AT1R gene A1166C polymorphism and essential hypertension of Xinjiang Uygur nationality

作　　者：湛文博 阿衣古丽.玉努斯 丁玮[3] 库热西.玉努斯 

机构地区：[1]新疆医科大学基础医学院生物化学与分子生物学教研室,新疆乌鲁木齐830054 [2]新疆医科大学第二附属医院药剂科,新疆乌鲁木齐830028 [3]新疆医科大学第一附属医院药剂科,新疆乌鲁木齐830054

出　　处：《吉林大学学报（医学版）》2014年第1期137-140,共4页Journal of Jilin University：Medicine Edition

基　　金：新疆医科大学地方病分子生物学重点实验室开放课题基金资助课题(XJDX0208-2010-04)

摘　　要：目的：探讨血管紧张素Ⅱ1型受体（AT1R）基因A1166C多态性与维吾尔族人群原发性高血压（EH）的关系，阐述ATIR基因A1166C在EH中的作用机制。方法：收集EH组167例、对照组469例、共636例维吾尔族人群血液样本，采用聚合酶链式反应-限制性片段长度多态性技术（PCR-RFLP）对ATIR基因A1166C进行多态性检测，分析AA、AC和CC3种基因型以及该位点A、C不同等位基因频率在EH组和对照组中的分布。结果：EH组AC＋CC基因型和C等位基因频率明显高于对照组，差异有统计学意义（χ2=10．179，P=0．001）；AC＋CC基因型人群患EH的危险度是AA基因型人群的1．6倍（OR=1．612，95％CI：1．191～2．183）。结论：AT1R基因A1166C多态性与维吾尔族EH的发病可能存在-定关联。Objective To investigate the association between angiotensin II type 1 receptor （AT1R） gene Al166C polymorphism and essential hypertension （EH） in Uygur nationality and to clarify the action mechanism of AT1R gene Al166C in the occurrence of EH. Methods 636 cases of Uyghur population blood samples including 167 cases of EH group and 469 cases of control group were collected. Then polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method was adopted to examine the AT1R gene Al166C polymorphism. The distribution of AA, AC and CC genotypes and the different frequencies of the points IA, C in EH and control groups were analyzed. Results The AC＋CC genotype and C allele frequency in EH group were significantly higher than those in control group, the difference was statistically significant （Z2 =10. 179 , P=0. 001） ; the risk of EH of the people with AC＋ CC genotypes was 1.6 （OR = 1. 612, 95 % CL：1. 191 -- 2. 183） times than that of the people with AA genotype. Conclusion There might be some relationship between AT1R gene Al166C polymorphism and the EH in Uighur population.

关 键 词：原发性高血压 血管紧张素Ⅱ1型受体 基因多态性 维吾尔族 

分 类 号：R544.1[医药卫生—心血管疾病]