淋巴细胞微核与超薄液基细胞学联合检测对宫颈癌早期诊断价值探讨  

The investigation on clinical value of lymphocyte micronucleus testing combined thinprep cytologic test in the early of cervical cancer

作　　者：李芳[1] 葛凤华[1] 王颖[1] 

机构地区：[1]威海市文登中心医院,山东威海264400

出　　处：《临床医药实践》2014年第1期45-46,73,共3页Proceeding of Clinical Medicine

摘　　要：目的:探讨淋巴细胞微核及超薄液基细胞学(TCT)联合检测对提高早期宫颈癌诊断的价值。方法:对住院的8 950例患者进行超薄液基细胞学检测,其中正常范围及良性反应性改变7 958例(88.9%),未明确意义的非典型鳞状上皮细胞(ACS)710例(7.9%),低度鳞状上皮细胞内瘤变Ⅰ级154例(1.7%),高度鳞状上皮细胞内瘤变Ⅱ,Ⅲ级91例(1.1%),宫颈癌18例(0.2%),非典型腺细胞17例(0.2%),同时进行淋巴细胞微核分析。结果:改良淋巴细胞微核检出率和平均微核细胞率两项指标随鳞状上皮细胞瘤变级别增高而增高,两者比较差异有统计学意义(P<0.01)。结论:淋巴细胞微核检出率和平均微核细胞率两项指标可作为宫颈癌早期诊断的重要指标。Objective：To research the clinical value of lymphocyte micronucleus testing combined Thinprep cytolog-ic test（TCT） in the early of cervical cance. Methods： All 8 950 cases of patients in hospital were being selected and ana-lyzed by thinprep cytologic test. Where the normal range and benign reactive changes 7 958 patients （88.9 %）, no mean- ing clearly atypical squamous cells （ACS） 710 patients （7.9 %）, low-grade squamous intraepithelial neoplasia grade Ⅰ 1 5 4 cases （ 1. 7 % ） , high - grade squamous epithelial neoplasia Ⅱ ,Ⅲ 9 1 cases （ 1. 1 % ） , cervical cancer 1 8 cases （0.2 % ）, atypical glandular cells in 17 patients （0.2 %）, while lymphocyte micronucleus assay. Results： With squamous cell neoplasia grade increased, the lymphocyte micronucleus two indicators were increased, and there have significant differences（P〈0.01）. Conclusion：Lymphocyte micronucleus detection rate and the average rate of micronucleus cells can be used as an important indicator of early diagnosis of cervical cancer.

关 键 词：淋巴细胞微核 超薄液基细胞学 价值 

分 类 号：R446[医药卫生—诊断学]