持续性皮下胰岛素输注对初诊2型糖尿病患者胰岛β细胞功能及脂联素、内脂素的影响  

The effect of β-cell function andAdiponectin、Visfatin in the Continuous Subcutaneous Insulin Infusion treatment of newly diagnosed type 2 diabetes

作　　者：胡郁刚 陈根本[2] 

机构地区：[1]广东省潮州市潮州医院内二科,广东潮州521000 [2]广东省潮州市潮安县庵埠华侨医院内二科,广东潮州515638

出　　处：《吉林医学》2014年第3期458-460,共3页Jilin Medical Journal

摘　　要：目的:观察短期持续性皮下胰岛素输注(Continuous Subcutaneous Insulin Infusion,CSII)对初诊2型糖尿病患者胰岛β细胞功能及脂联素、内脂素的影响。方法:将62例初诊2型糖尿病患者随机分为治疗组与对照组,治疗组采用CSII,对照组仅皮下注射胰岛素,疗程共2周,比较两组治疗前后胰岛β细胞功能指标的变化,治疗前后均检测脂联素、内脂素,计算HOMA-IR(C-P),比较两组治疗前后胰岛素抵抗的变化。结果:治疗后,治疗组胰岛β细胞分泌功能、脂联素均显著升高,内脂素和胰岛素抵抗指数显著降低。差异有统计学意义(P<0.05)。结论:持续性皮下胰岛素输注对初诊2型糖尿病患者有积极作用。Objective To observe the short-term continuous subcutaneous insulin infusion in patients with newly diagnosed type 2 diabetes, β - cell function and adiponectin, visfatin effects.Methods 62 patients were randomly divided into treatment and control groups,treatment group with CSII,the control group,only subcutaneous insulin injections daily for 2 weeks,two groups were compared before and after treatment of β -cell function index changes.Before and after treatment are within a detecting adiponectin, visfatin,calculated HOMA-IR（C-P）.Results After treatment,the treatment group islet 13 -cell secretion,adiponectin were significantly elevated,visfatin and insulin resistance index decreased significantly.The difference was statistically significant（P 〈 0.05）.Conclusion Continuous subcutaneous insulin infusion for first diagnosis in oatients with tvoe 2 diabetes have a positive effect.

关 键 词：持续性皮下胰岛素输注 2型糖尿病 Β细胞功能 脂联素 内脂素 

分 类 号：R587.1[医药卫生—内分泌]