白钩藤的化学成分研究  

Chemical constituents in stems with hooks of Uncaria sessilifructus

作　　者：张茂娟[1,2] 刘冰[2] 安彦峰 冯德强[1] 许又凯[2] 

机构地区：[1]云南中医学院,云南昆明650204 [2]中国科学院西双版纳热带植物园,云南勐腊666303

出　　处：《中草药》2014年第2期175-180,共6页Chinese Traditional and Herbal Drugs

基　　金：国家中医药管理局中医药重点学科建设项目(20270101805/002)

摘　　要：目的研究白钩藤Uncaria sessilifructus带钩茎枝的化学成分。方法采用硅胶、MCI、Sephadex LH-20等柱色谱方法分离纯化,根据理化性质及波谱数据鉴定化合物结构。结果从白钩藤干燥带钩茎枝95%乙醇提取物中分离得到了14个非生物碱类化合物:木栓酮(1)、桦木醇(2)、钝鸡蛋花素(3)、豆甾-4-烯-3-酮(4)、β-谷甾醇(5)、β-胡萝卜苷(6)、24-烯-环阿尔廷酮(7)、角鲨烯(8)、维生素E(9)、α-tocopherolquinone(10)、(-)-alloaromadendrene(11)、丁香色酮(12)、东莨菪内酯(13)、bis(2-ethylhexyl)phthalate(14);3个吲哚生物碱类化合物:大叶帽柱木碱(15)、异大叶帽柱木碱(16)、isomitraphylline N-oxide(17)。结论化合物1、4、8、11、13为首次从钩藤属植物中分离得到,所有化合物均为首次从白钩藤中分离得到。Objective To study the chemical constituents from the stems with hooks of Uncaria sessilifructus. Methods The chemical constituents were isolated and purified by chromatography on silica gel, MCI, Sephadex LH-20 columns, etc. The structures of compounds were elucidated by spectral analyses. Results Fourteen non-alkaloids compounds were isolated from the 95% ethanol extract from the stems with hooks of U. sessilifructus, and the structures were identified as friedelin （1）, betulin （2）, obtusalin （3）, stigmast-4-en-3-one （4）, β-sitosterol （5）, 13-daucosterol （6）, 24-en-cycloartenone （7）, squalene （8）, vitamin E （9）, a-tocopherolquinone （10）, （-）-alloaromadendrene （11）, eugenin （12）, scopoletin （13）, and his （2-ethylhexyl） phthalate （14）; Three alkaloids were identified as mitraphylline （15）, isomitraphylline （16）, and isomitraphylline N-oxide （17）. Conclusion compounds 1, 4, 8, 11, and 13 are obtained from the plants of genus Uncaria Schreber nom. cons. for the first time, and all the above compounds are obtained from the stems with hooks of U. sessilifructus for the first time.

关 键 词：白钩藤 生物碱 木栓酮 桦木醇 Β-谷甾醇 东莨菪内酯 大叶帽柱木碱 

分 类 号：R284.1[医药卫生—中药学]