治疗艾滋病中药复方制剂研究现状与新思路  

Study status and new thoughts on Chinese materia medica formula used for AIDS treatment

作　　者：李艳萍[1,2] 和丽生[2] 赵远[2] 王莉[2] 曹玺[2] 邓家刚[3] 

机构地区：[1]广西医科大学,广西南宁530021 [2]云南省中医中药研究院,云南昆明650223 [3]广西中医药大学,广西南宁530021

出　　处：《中草药》2014年第3期303-307,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81160537);云南省科技厅科技惠民专项项目"延缓艾滋病病程进程的中医药临床治疗关键技术研究及应用示范"(2013CA020)

摘　　要：国外已经报道的艾滋病"功能性治愈"是在患者感染初期未形成病毒存储库的情况下实现的,尚属个例,治疗艾滋病有效的药物仍然是国内外很多学者研究的主要目标和方向。中医药在艾滋病的防治过程中进行了积极的探索和研究,开发了许多中药复方应用于临床并取得成效,但由于中药复方的特殊性,即物质基础不明、靶点不清等缺陷,中药复方制剂在艾滋病防治研发方面存在公认度不足、与现代技术结合程度不高导致发展缓慢、获准新药率不高的瓶颈。因此,结合近年来国内外报道的治疗艾滋病中药复方研究进展,探讨了在中医理论指导下,应用"有效部位(成分)配伍组方"、"吸收/代谢复方原成分配伍"、"循证药学临床筛方"等新思路研究治疗艾滋病中药复方制剂的可行性和挑战性,为开发治疗艾滋病中药新药提供新思路和尝试。＂HIV/AIDS Functional Cure＂ has been reported to apply to those infected individuals without persistence of various HIV viral reservoirs. To find the effective medicines in the treatment of AIDS is still a direction and aim for lots of scholars. Chinese materia medica formula （CMMF） is used to treat HIV/AIDS in clinic, and a lot of researches and exploration have been carried out. However, the particularities of CMMF were as follows： the material basis is unknown; the target is not clear and other defects so on. The factors restricting the development of CMMF for AIDS included the lack of recognization and combination with modem technology. Many CMMFs are difficult to be registered by SFDA. Combined with the recent research progress in the CMMF treatment of AIDS and under the guidance of traditional Chinese medicines theory, the paper discusses the feasibility and challenges in the application of the study on the development of new CMMF for HIV/AIDS. With the new method as ＂Active Ingredient Combination＂, ＂Absorption/metabolic Compound Compatibility of Original Composition＂, and ＂Evidence-based Medicine Clinical Screening＂, we could provide the new thoughts and try to AIDS treatment with CMMF.

关 键 词：艾滋病 中药复方 吸收 代谢复方原成分配伍 循证药学临床筛方 新思路 功能性治愈 

分 类 号：R28[医药卫生—中药学]