液晶自适应光学视网膜校正成像技术研究  

Retinal correction imaging system based on liquid crystal adaptive optics

作　　者：郑贤良[1,2] 刘瑞雪[1,2] 夏明亮[3] 曹召良[1] 宣丽[1] 

机构地区：[1]中国科学院长春光学精密机械与物理研究所应用光学国家重点实验室,吉林长春130033 [2]中国科学院大学,北京100049 [3]中国科学院苏州生物医学工程技术研究所江苏省医用光学重点研究室,江苏苏州215163

出　　处：《中国光学》2014年第1期98-104,共7页Chinese Optics

基　　金：国家自然科学基金资助项目(No.60736042;No.1174279;No.1174274);苏州市科技发展计划资助项目(No.ZXS201001)

摘　　要：为了实现对人眼视网膜的高分辨率成像，解决偏振能量损失、成像视场小和普适性差等问题，对液晶自适应光学技术及其在人眼视网膜成像中的应用进行了研究。通过开环光路的设计方案，避免了闭环液晶自适应系统的偏振光能量损失；在光路中加入可变视场光阑，利用小视场照明进行波前探测、大视场照明进行像差校正和成像的方法扩大了成像视场；使用脉冲光照明的方案减小曝光量；通过偏振光照明提高能量利用率、等效无穷远视标配合补偿镜以及改进后的视标提高盯视稳定性等一系列方法，提高系统普适性。校正后成像的清晰度和对比度获得了明显提高；高分辨率眼底成像视场直径从200μm扩大到500μm；曝光量减小到原来的1/2～1/3；对前期难以获得清晰成像的样本，取得了效果良好的视网膜视觉细胞自适应图像。In order to realize high resolution retinal imaging , the technique of Liquid Crystal Adaptive Optics （ LC-AO） and its utilize in retinal imaging is under investigation .Problems are settled in the research such as energy loss by polarization , limitation on field of view （ FOV） and universality of LC-AO system in retinal ima-ging.Open-loop adaptive optics system is introduced to avoid the energy loss by polarization in closed -loop system.View field of imaging system is expanded by adhibition of an alterable diaphragm .Exposure ratio is＆amp;nbsp;reduced by a pulsed light source .Illumination is polarized to increase energy efficiency .Trial lens and dynam-ic, advanced target at infinite are used to increase the stability of pupil and reduce the impact of individual differences on human-eyes.Definition and contrast of images after correction are remarkably increased .FOV is enhanced from 200 μm to 500 μm.Exposure ratio is reduced to 1/2 ~1/3.High definition images are taken from samples with low resolution before .Most problems of LC-AO system for high resolution retinal ima-ging are settled .

关 键 词：自适应光学 液晶波前校正器 视网膜成像 开环 大视场 

分 类 号：O439[机械工程—光学工程] TH74[理学—光学]