雌激素替代疗法与绝经后帕金森病关系的Meta分析  

Relationship between the estrogen replacement therapy and postmenopausal Parkinson's disease: a Meta-analysis

作　　者：吕震[1] 王取南[1] 陆林玲[1] 魏敏[2] 

机构地区：[1]安徽医科大学公共卫生学院卫生毒理学系,安徽合肥230032 [2]安徽医科大学卫生管理学院,安徽合肥230032

出　　处：《中华疾病控制杂志》2014年第2期139-142,共4页Chinese Journal of Disease Control & Prevention

基　　金：国家自然科学基金(30571585)

摘　　要：目的综合分析绝经后妇女帕金森病（Parkinson’s disease，PD）发病情况与雌激素替代疗法（estrogenreplacementtherapy，ERT）之间的关系。方法检索PubMed、EMBASE、TheCochraneLibrary等外文数据库，中国生物医学文献数据库（CBM）、CNKI、万方和维普数据库等中文数据库，收集雌激素替代疗法与绝经后妇女PD相关性的病例对照研究，对检索到的文献进行质量评价后，采用RevMan5．0软件对提取的数据进行分析。结果本研究共纳入5项病例对照研究，病例组633人，对照组752人。Meta分析结果显示雌激素替代疗法与绝经后妇女PD发病情况之间差异无统计学意义（OR=0．78，95％CI=0．45～1．37，P=0．394）。结论雌激素替代疗法与绝经后妇女PD发病情况无相关性。Objective To investigate the association between parkinson＇s disease incidence in postmenopausal women and estrogen replacement therapy. Methods The case-control studies from PubMed, EMBASE, The Cochrane Li- brary, CBM, CNKI, WANFANG, VIP database for the association between Estrogen Replacement Therapy and Parkinson＇ s disease of postmenopausal women were searched. The quality of the included studies was evaluated, RevMan 5.0 software was used to analyze the extracted data. Results ＂ Five case-control studies with 633 cases and 752 controls were analyzed. Meta analysis showed no significant association between estrogen replacement therapy and risk of parkinson＇ s disease in postmenopausal women between Parkinson and the incidence of no statistical significance （ OR = 0. 78,95% CI = 0. 45- 1.37,P = 0. 394）. Conclusions Estrogen replacement therapy in postmenopausal women has no correlation with Parkin- son＇ s disease.

关 键 词：雌激素替代疗法 帕金森病 META分析 

分 类 号：R181[医药卫生—流行病学] R749.1[医药卫生—公共卫生与预防医学]