差示扫描量热法测定草酸艾司西酞普兰纯度  

Determination of Escitaliporam Oxalate Purity by Differential Scanning Calorimetry Method

作　　者：张颖卓[1] 崔秀兰[1] 杨庆云[2] 吴松[2] 

机构地区：[1]内蒙古工业大学,呼和浩特010000 [2]中国医学科学院药物研究所,北京100050

出　　处：《化学分析计量》2014年第1期57-60,共4页Chemical Analysis And Meterage

摘　　要：采用差示扫描量热法（DSC），根据DSC曲线利用纯度分析软件测定草酸艾司西酞普兰的纯度。对实验条件进行了优化，升温速率为4.0 K/min，称样量为2～3.2 mg。测得草酸艾司西酞普兰的纯度为99.17%，相对标准偏差为0.05％（n=6）。该法测定结果与非水滴定法测定结果（99.24％）基本一致。差示扫描量热法可用于测定草酸艾司西酞普兰纯度，方法操作简便、结果准确。The differential scanning calorimetry （DSC） technique was used to determine the purity of escitalopram oxalate, according to the DSC curve and by using the purity analysis software. The experimental conditions were optimized, the heating rate was 4.0 K/min and the sample mass was 2-3.2 mg. The purity result determined by DSC method was 99.17%, RSD was 0.05%（n=6）. The result was consistent with the result （99.24%） determined by the non-aquseous trirtation method. The DSC method is accurate and simple for the determination of escitalopram oxalate purity.

关 键 词：草酸艾司西酞普兰 纯度 差示扫描量热法 非水滴定法 

分 类 号：O657.99[理学—分析化学]