左炔诺孕酮宫内缓释系统治疗子宫腺肌病近期疗效观察  

The recent curative effect observation of levonorgestrel intrauterine sustained release system in treatment of adenomyosis

作　　者：黄荣芳[1] 张燕萍[1] 储丽萍[1] 高俊丽[1] 

机构地区：[1]云南省昆明市妇幼保健院,650031

出　　处：《中国妇幼保健》2014年第5期679-681,共3页Maternal and Child Health Care of China

基　　金：云南省教育厅青年基金项目〔Q200925587〕

摘　　要：目的:对左炔诺孕酮宫内缓释系统(LNG-IUS)用于子宫腺肌病治疗的临床疗效进行研究分析。方法:对34例子宫腺肌病患者子宫内放入LNG-IUS前后进行观察,包括痛经水平、子宫体积改变、血清CA123、月经状况和不良反应。结果:子宫内放入LNG-IUS 3个月后痛经水平降低,6个月后无痛经症状,痛经程度分数变为(1.30±0.16)分,放置前为(2.50±0.41)分,P<0.01;子宫体积放置后变小,6个月后体积为(152.26±13.24)cm3,放置前体积为(160.15±35.05)cm3;血清CA125数值显著下降,3个月后数值下降到(25.36±11.27)U/ml,放置前为(67.32±16.84)U/ml(P<0.01);患者月经量在放置后明显下降,3个月后只有原来月经量的(28.00±8.00)%,P<0.01;患者在放置LNG-IUS后未出现任何不良反应。结论:子宫腺肌病用左炔诺孕酮宫内缓释系统治疗有明显疗效,具有高安全性。Objective： To observe the effect of levonorgestrel releasing intrauterine system （ LNG - IUS） for adenomyosis treatment clinical analysis. Methods： 34 cases of adenomyosis uterus into before and after LNG - IUS were observed, including dysmenorrhea, uterine volume change, the level of serum CA123, menstrual status and adverse reaction. Results： The womb after three months of LNG - IUS, dysmenorrhea decreased after 3 months, no symptoms of dysmenorrhea after 6 months, the degree of dysmenorrhea scores was （ 1.30 ± 0. 16）, （2. 50 ±0. 41 placed before） （P 〈 0. 01 ） . Uterine volume was smaller, 6 months after the volume was （ 152. 26± 13.24） cm3, placed before the volume was （ 160. 15 ±35.05 ） cm3. Serum CA125 value was decreased significantly, after 3 months of numerical was decreased to （25.36 ± 11.27） U/ml, （67.32 ± 16. 84 U/ml placed before） （P 〈0. 01 ） . Patients in menstrual quantity were decreased obviously after the in place, only the original menstruation after 3 months was （28 ± 8） % （P 〈 0. 01 ） . There was not any adverse reactions in patients after LNG -IUS placement. Conclusion： LNGIUS has obvious curative effect and high safety on adenomyosis.

关 键 词：左炔诺孕酮宫内缓释系统 子宫腺肌病 痛经 月经 

分 类 号：R711.74[医药卫生—妇产科学]