35岁以下妇女卵巢上皮性癌77例临床分析  

Clinical analysis of 77 cases of ovarian epithelial carcinoma below 35 years old

作　　者：翟琳[1] 陈银萍[2] 梁健[3] 付艳[1] 

机构地区：[1]吉林大学第一医院普通妇科,吉林长春130000 [2]余姚市人民医院妇产科 [3]佳木斯大学附属第一医院

出　　处：《中国妇幼保健》2014年第5期693-696,共4页Maternal and Child Health Care of China

摘　　要：目的：探讨年轻卵巢上皮性癌患者的临床特点、治疗及与预后的相关性。方法：对77例〈35岁的卵巢上皮性癌患者的临床资料进行回顾性分析。结果：77例35岁以下卵巢上皮性癌患者2年生存率为73．53％，5年生存率为63．19％，以腹痛为最常见首发症状，确诊时I期44例，Ⅱ期8例，Ⅲ期22例，Ⅳ期3例。最常见的病理类型为浆液性囊腺癌（32例），以高分化多见（32例），平均肿瘤最大径线为10．7em。23例患者保留了生育功能，其中2例于术后成功足月妊娠。临床分期I期一Ⅳ期患者的2年生存率分别为94．87％、83．33％、40．00％及0，5年生存率分别为89．74％、50．00％、25．00％及0，Ⅱ期与Ⅲ期患者的生存率无明显统计学差异，各临床分期生存率两两比较均有统计学差异（P〈0．05）。临床分期、病理类型、细胞学分级、肿瘤残余大小、肿瘤位于单／双侧对预后有影响（P〈0．05），年龄对于预后无影响。肿瘤残余大小是影响预后的独立因素（P〈0．05）。结论：35岁以下卵巢上皮性癌妇女临床期别早、分化好，预后相对较好，临床分期、病理类型、细胞学分级、肿瘤残余大小、肿瘤位于单／双侧对预后有影响，年龄对于预后无影响。肿瘤残余大小是影响预后的独立因素。Objective： To study the clinical characteristics, treatment and prognosis of ovarian epithelial carcinoma in young women below 35 years old. Methods： A total of 77 cases of epithelial ovarian carcinoma of women less than 35 years old were analyzed retro- spectively. Results： The 2 -year and 5 - year survival rate of 77 cases was 73.53% and 63. 19%, respectively. Abdominal pain was the most common first symptom and at the time of diagnosis, 44 patients had stage I disease, 8 patients had stage II disease, 22 patients had stage Ill disease and 4 patients had stage IV disease. Serous cystadenocarcinoma was the most common pathologic type, and most of them were well - differentiated tumor, average maximum diameter of tumor was 10. 7 cm. 23 patients underwent fertility - sparing treatments, 2 of them had succeeded in achieving term pregnancies after surgeries. 2 -year survival rates of stage I - IV patients was 94. 87%, 83.33%, 40. 00% , 0, and 5 - year suvival was 89. 74%, 50. 00%, 25.00%, 0, except in stage II and stage In, there were significant differences between any other two stage （ P 〈 0. 05 ） . Clinical stage, pathologic type, histological grade, residual tumor size, lateral were prognostic factors of ovarian epithelial carcinoma in young women （P 〈 0. 05）, which age was not, and residual tumor size was independent prognostic factors affecting ovarian cancer （ P 〈 0. 05） . Conclusion：Earlier staging, good cell differentiation, clinical stage, pathologic type, histological grade, residual tumor size, lateral were prognostic factors of ovarian epithelial carcinoma in young women, which age is not, and residual tumor size is independent prognostic factors affecting ovarian cancer.

关 键 词：卵巢癌 年轻妇女 临床特点 预后 

分 类 号：R711.75[医药卫生—妇产科学]