纳米尺度金属超分子配合物对DNA的特殊识别与功能调控新进展  

Recent progress in specific recognition and modulation of DNA by nano-metallo-supramolecular complexes

作　　者：赵传奇[1] 曲晓刚[1] 

机构地区：[1]中国科学院长春应用化学研究所,稀土资源利用国家重点实验室,长春130022

出　　处：《科学通报》2014年第2期116-121,共6页Chinese Science Bulletin

基　　金：国家重点基础研究发展计划(2011CB936004);国家自然科学基金(21210002;91213302;21202158)资助

摘　　要：配体通过靶向特殊基因,进而调节该基因所参与的生物学功能一直是生物无机化学领域十分活跃的研究课题.当前,金属配合物对DNA的结构识别以及功能调控引起了人们的高度重视,越来越多的研究表明,金属配合物能够有效地识别DNA的二级结构并影响其生物学功能.最近研究发现,一些具有纳米尺度的金属超分子配合物能够特异性识别DNA并表现出特殊的生物学效应.本文总结了纳米尺度金属超分子配合物对不同DNA二级结构的选择性识别及调控等方面的研究进展.There is great interest in design and synthesis of ligands which selectively target specific genes to inhibit biological functions in which particular DNA structures participate. Among these studies, DNA structural recognition and functional regulation by metal complexes have received much attention because several metal complexes have shown specific interactions with DNA secondary structure and even regulation of DNA biological functions. Recent studies have demonstrated that metallo-supramolecular complexes with nanoscale can recognize different DNA structures and exhibit special preference. This review summarizes recent progress in nano-metaUo- supramolecular complexes binding to various DNA secondary structures and their selectivity and specificity.

关 键 词：纳米尺寸金属 超分子配合物 核酸 分子识别 G-四链DNA 手性识别 

分 类 号：O629.7[理学—有机化学]