无机纳米材料的生物催化活性  

The biocatalytic activity of inorganic nanomaterials

作　　者：张一[1,2] 田甜[1,2] 孙艳红[1] 诸颖[1] 黄庆[1] 

机构地区：[1]中国科学院上海应用物理研究所物理生物学实验室,上海201800 [2]中国科学院大学,北京100049

出　　处：《科学通报》2014年第2期158-168,共11页Chinese Science Bulletin

基　　金：国家自然科学基金(11179004;11275251;U1232113;U1232114);国家重大科学研究计划(2012CB825805)资助

摘　　要：目前,无机纳米材料模拟生物酶催化活性的报道得到了纳米技术领域的广泛重视,模拟葡萄糖氧化酶的纳米金和过氧化物酶的磁性纳米颗粒就是其中的典型代表.与常规的生物酶相比,无机纳米颗粒稳定性较强,受酸碱、温度等因素的影响较小;而且易于制备和纯化,生产成本低,容易被标记和修饰,具有广泛的研究和应用前景.此外,由于无机纳米材料低毒、生物相容性好的特点,这些纳米颗粒还有望在生命体的生理代谢过程中发挥重要的作用.相关的研究已经证明了无机纳米材料的酶学性质,并在催化机理层面进行了初步的探讨.本文综述了无机纳米材料在生物酶催化活性方面的研究进展与应用前景,希望能够为此类纳米材料更加科学合理地运用于生物催化领域提供参考.The inorganic nanomaterials have received considerable attention in nanotechnology field because of their biocatalytic activity, such as gold nanoparticles and Fe304 nanoparticles. Compared to biologic enzymes, inorganic nanoparticles have the better stability, biocompatibility, and can be easily modified and marked. These properties make it possible that inorganic nanomaterials could play an important role in the physiological and metabolic processes in the living body. A series of recent papers have implicated the enzymatic properties of nanomaterials and preliminary catalytic mechanisms. This review aims to summarize recent research on biocatalytic activity of the inorganic nanoparticles and provide useful information for the design of biologic enzymes based on inorganic nanoparticles.

关 键 词：无机纳米材料 生物催化活性 纳米金 磁性纳米颗粒 

分 类 号：TB383.1[一般工业技术—材料科学与工程]