血液透析患者血浆中血小板源性生长因子BB的表达及意义  

Expression of platelet derived growth factor-BB in maintence hemodialysis patients

作　　者：曾宇然[1] 王伟鸿[1] 卢敏[1] 严丽君[1] 

机构地区：[1]汕头大学医学院第一附属医院血液净化科,广东汕头515041

出　　处：《中国实用医刊》2014年第3期4-6,共3页Chinese Journal of Practical Medicine

基　　金：2011汕头市重点科技计划（汕府科[2011]46）

摘　　要：目的测定血液透析患者血小板源性生长因子BB（PDGF—BB）水平，探讨其在血液透析患者颈动脉粥样硬化发生发展中的意义。方法选择维持性血液透析患者68例，应用彩色多普勒超声显像仪检查两组样本的颈动脉内膜-中层厚度（IMT）及所探测到的斑块情况，将其分为合并颈动脉粥样硬化组和无合并颈动脉粥样硬化组，然后采用酶联免疫吸附法测定两组样本的血浆PDGF—BB水平及血小板第4因子（PF4）水平，对两组研究指标进行统计学分析。结果维持性血液透析患者颈动脉粥样硬化阳性率为69．1％，合并颈动脉粥样硬化组血浆PDGF—BB水平均较无合并颈动脉粥样硬化组高[（1044-28）psimlVS（76±15）pg／ml，P〈0．01]，PF4水平同样是增高的[（578±125）ng／LVS（457±60）ng／L，P〈0．05]；多元线性逐步回归分析显示血液透析患者血浆PDGF—BB水平、患者年龄均为影响颈动脉IMT的重要因素。结论血液透析患者血浆PDGF．BB水平增高对其颈动脉粥样硬化发生有重要作用。Objective To measure the platelet derived growth factor-BB （PDGF-BB） levels in maintence hemodialysis patients and investigate its significance in carotid atherosclerosis. Methods Six- ty-eight patients with hemodialysis were enrolled in this study. Intima-media thickness（IMT） and preva- lence of atherosclerotic plaques of the extracranial common carotid artery were measured by echocardio- graphy. The serum PDGF-BB and platelet factor4 （PF4） were measured by enzyme-linked immunosorbent assay in all patients. Results The level of serum PDGF-BB in atherosclerosis group of hemodialysis pa- tients were significantly higher than that in the non-atherosclerotic plaques group [ （104± 28 ）pg/ml vs （76 ± 15 ） pg/ml,P 〈 0. 01 ], the level of serum PF4 in atheroselerosis group of hemodialysis patients were significantly higher than that in non-atherosclerotic plaques group[ （578 ± 125 ）ng/L vs （457±60）ng/L, P 〈 0. 05 ]. Multiple stepwise regression analysis indicated that the factor impacting IMT were level of PDGF-BB and age. Conclusions The level of serum PDGF-BB is raised in maintence hemodialysis pa- tients, it maybe play an important role in the formation of carotid atherosclerosis.

关 键 词：血小板源性生长因子BB 血液透析 动脉粥样硬化 

分 类 号：R459.5[医药卫生—治疗学]