枇杷叶黄酮类化学成分研究  

Studies on the flavonoids from leaf of Eriobotrya japonica( Thunb. ) Lindl.

作　　者：吕寒[1] 于盱[1] 陈剑[1] 李维林[1] 

机构地区：[1]江苏省.中国科学院植物研究所,江苏南京210014

出　　处：《中成药》2014年第2期329-332,共4页Chinese Traditional Patent Medicine

基　　金：国家自然科学基金项目(21102058);江苏省科技基础设施建设计划-科技公共服务平台项目(BM2011117)

摘　　要：目的研究中药枇杷叶中黄酮类化学成分。方法采用反复硅胶、反相硅胶、凝胶LH-20柱以及制备薄层等方法分离枇杷叶黄酮提取物中的化学成分,运用化学和有机波谱分析方法确定化合物结构。结果从枇杷叶中分离得到9个黄酮类化合物,经鉴定分别为山柰酚(1),槲皮素(2),3,5,7-三羟基黄酮(高良姜素)(3),橙皮苷(4),金丝桃苷(5),山柰酚-3,7-二葡萄糖苷(6),异槲皮苷(7),槲皮苷(8),芦丁(9)。结论化合物3、4和6为首次从该植物及该属植物中分离得到。AIM To investigate the flavonoids from loquat leaf( Eriobotrya japonica( Thunb.) Lindl.). METHODS Compounds from Loquat leaf were isolated by a combination of silica gel,ODS,sephadex LH-20 column chromatographies and preparative TLC. Their structures were identified by chemical and spectral methods. RESULTS Nine flavonoids were isolated and identified as kaempferol( 1),quercetin( 2),galangin( 3),hesperidin( 4),hyperoside( 5),kaempferol-3,7-diglucoside( 6),isoquercetin( 7),quercetrin( 8),rutin( 9) from loquat leaf. CONCLUSION Compounds 3、4 and 6 are obtained from this plant and Eriobotrya genus for the first time.

关 键 词：枇杷叶 化学成分 黄酮 

分 类 号：R284.1[医药卫生—中药学]