不同煎煮方法对麻杏石甘汤中成分变化研究  

Contents variation for Maxing Shigan Decoction by different boiling methods

作　　者：饶毅[1] 张五萍[2] 魏惠珍[3] 高萌[3] 金浩鑫[1] 王跃生[4] 

机构地区：[1]中药固体制剂制造技术国家工程研究中心,江西南昌330006 [2]江西省人民医院,江西南昌330006 [3]江西中医药大学,江西南昌330006 [4]中国中医科学院中药研究所,北京100700

出　　处：《中成药》2014年第2期337-341,共5页Chinese Traditional Patent Medicine

基　　金：国家重点基础研究发展计划(2010CB530602)

摘　　要：目的优化麻杏石甘汤(麻黄、杏仁、石膏、炙甘草)的煎煮方法。方法采用HPLC法,测定不同煎煮方法所得麻杏石甘汤中麻黄碱、伪麻黄碱、苦杏仁苷、甘草苷、甘草酸的量;采用ICP-AES,测定金属元素的量。结果麻黄先煎与麻黄石膏先煎均利于麻黄碱、伪麻黄碱的溶出,而且麻黄石膏先煎有利于金属元素的溶出。结论麻黄石膏先煎是麻杏石甘汤最合理的煎煮方法。AIM To inspect currently existing decoction methods of Maxin Shigan Decoction （Ephedrae Herba, Armeniacae Semen a marum, Gypsum fibrosum, Glycyrrhizae Radix et Rhizoma praeparata cum melle ） , to find the opti- mal processing methods. METHODS The contents of ephedrine, pseudoephedrine, amygdalin, glycyrrhizin, and glycyrrhizic acid in Maxin Shigan Decoction were determined by HPLC, and the contents of metal elements were de- termined by ICP-AES. RESULTS The method of ephedra decocted first and method of ephedra and gypsum decoc- ted first were conducive to the dissolution of ephedrine and pseudoephedrine. The latter method was especially condu- cive to the dissolution of the metal elements the most reasonable decoction for the clinical CONCLTIONS The method of ephedra and gypsum decocted first is use of Maxin Shigan Decoction.

关 键 词：麻杏石甘汤 煎煮方法 药效成分 

分 类 号：R284.1[医药卫生—中药学]