西北汉族原发性高血压患者β2肾上腺素能受体多态性对血管硬化及心室重构的影响  

Genetic influences of β2 adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients with northwest han nationality

作　　者：袁铭[1] 栗程 郭文怡[1] 李成祥[1] 王海昌[1] 

机构地区：[1]第四军医大学西京医院心脏内科,西安710032 [2]西安市第五人民医院干部病房

出　　处：《中华临床医师杂志（电子版）》2013年第22期50-52,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(81200189)

摘　　要：目的探讨西北汉族原发性高血压患者并发症和β2肾上腺素能受体单核苷酸基因多态性的关系。方法采用院内交叉研究,共入选300例原发性高血压病患者,诊断标准为收缩压(SBP)/舒张压(DBP)≥140/90 mm Hg,既往有高血压史,目前正在使用抗高血压药物,现血压虽未达到上述水平,亦应诊断为原发性高血压。所有入选对象均参照此标准入组,用Taqman PCR方法测定β2肾上腺素能受体Gly16Arg和Glu27Gln两种多态性。观测了左心室肥大(CRT心电图及超声心动图方法)及心脏扩大情况(CTR,胸部X线片)。结果与其他基因型比较,Arg/Arg基因型的收缩压较高(P=0.041<0.05)。PWV在各基因型之间无统计学差异(P>0.05);与其他基因型相比,Gln27Gln基因型的反应性充血、心电图显示的左心室肥大及左心室质量指数均明显降低(P<0.05)。心胸比率及NTG诱导的反应性充血在各组间也无明显变化(P>0.05)。结论β2肾上腺素能受体Gly16Arg和Glu27Gln两种基因多态性与动脉硬化及心室重构具有一定关系。Objective β2 adrenoreceptor is involved in the sympathetic nervous system, which plays an important role in the development of hypertension and hypertensive complications. These complications can include left ventricular hypertrophy and arterial stiffness, which are reported risk factors for cardiovascular diseases. We designed clinical trials to clarify the association between the hypertensive complications and β2 adrenoceptor single nucleotide polymorphisms in essential hypertension. Methods Using Taqman PCR methods, we detected two polymorphisms of β2 adrenoceptor Gly16Arg and Glu27Gln were detected using Taqman PCR methods. Three hundred subjects were included and measured pulse wave velocity, vasodilator response to hyperemia, left ventricular hypertrophy （by electrocardiogram and echocardiography）, and cardiac enlargement （by chest X ray）. Results Compared with other genotypes, the systolic pressure of Arg/Arg was higher （P=0.041,〈0.05）. PWV showed no difference among genotypes （P〉0.05）; The genotype Glu27Gln was found by both electrocardiogram and echocardiography significantly associated with left ventricular hypertrophy （P〈0.05）,and pulse wave velocity and nitroglycerin induced hyperemia were not found associated with these two polymorphisms. Conclusion These data suggested that two polymorphisms of β2 adrenoreceptor subtype Gly16Arg and Glu27Gln may have some genetic influences on atherosclerosis and ventricular remodeling in essential hypertension.

关 键 词：高血压 受体 肾上腺素能β2 多态性 单核苷酸 肥大 左心室 脉搏波速率 

分 类 号：R544.1[医药卫生—心血管疾病]