肾小管上皮-间充质转化的研究现状  

Research status of tubular epithelial-mesenchymal transition

作　　者：李旭艳[1] 谢院生[1] 陈香美[1] 

机构地区：[1]解放军总医院肾脏病科 全军肾脏病研究所 肾脏疾病国家重点实验室,北京100853

出　　处：《中华肾病研究电子杂志》2013年第2期42-46,共5页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：国家重大科学研究计划项目(2011CB944004);国家自然科学基金面上项目(30971377)

摘　　要：肾小管间质纤维化(TIF)几乎是所有慢性肾脏病进展至终末期肾病(ESRD)的最终共同通路,肾小管上皮-间充质转化(EMT)是TIF的关键发病机制,成为目前肾脏领域研究的热点。本文旨在综述肾小管EMT的研究现状,总结目前肾小管EMT研究存在的问题及展望,为今后肾小管EMT的研究以及TIF的治疗提供新的思路。Renal tubular interstitial fibrosis （TIF） is the final common pathway of a wide variety of chronic kidney diseases that eventually lead to end-stage renal disease （ESRD）. Growing evidence has implicated tubular epithelial-mesenchymal transition （EMT） as a major pathway leading to TIF in diseased kidneys. Therefore, EMT has become the focus of research in kidney diseases. The purpose of this study is to review the status of renal tubular EMT. It also summarizes the remaining problems and prospects for future research to provide new clues for the study of tubular EMT as well as the treatment of TIF.

关 键 词：肾小管 上皮-间充质转化 肾小管间质纤维化 

分 类 号：R692[医药卫生—泌尿科学]