9p21染色体单核苷酸多态性与冠心病相关性的研究进展  

The 9p21 chromosome polymorphism and coronary artery disease:A research progress

作　　者：李建飞[1] 房秋菊[2] 张明宇[1] 

机构地区：[1]哈尔滨医科大学附属第四医院心内科,黑龙江哈尔滨150001 [2]黑龙江省医院心内科,黑龙江哈尔滨150038

出　　处：《中国现代医生》2014年第2期4-7,共4页China Modern Doctor

基　　金：黑龙江省自然科学基金(H201388)

摘　　要：冠心病是全世界范围内导致死亡的疾病,全基因组关联研究(GWAS)发现了许多与冠心病相关的易感基因位点。本文综述9p21染色体单核苷酸多态性(SNP)和冠心病的关系,9p21风险基因的表达不仅增加冠心病的发病率,同时提高心肌梗死的发病率,并与早发冠心病和再发心肌梗死相关联,但目前基因造成冠心病高发的具体作用途径仍不清楚。Coronary heart disease is the leading cause of death worldwide. Many susceptibility genes associated with CHD had been identified by GWAS. This article reviews the association of single-nucleotide polymorphisms on chro- mosome 9p21 with the the risk of CHD. The presence of a risk allele at 9p21 locus increased the risk of myocardial infaction as well as CHD. In addition, it significantly associates with premature CHD and recurrent MI. The mecha- nism of genetic variants triggered the pathogenesis of CHD remains to be clarified.

关 键 词：9p21染色体 单核苷酸多态性 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]