右旋美托咪啶对七氟醚复合瑞芬太尼麻醉期间麻醉深度的影响  

Effects of dexmedetomidine on the depth of anesthesia during sevoflrane combined with remifentanil

作　　者：周涛[1] 

机构地区：[1]泰安市第四人民医院麻醉科,271000

出　　处：《中国实用医药》2014年第2期15-16,共2页China Practical Medicine

摘　　要：目的观察吸入七氟醚复合瑞芬太尼麻醉期间,右旋美托嘧啶对脑电双频谱指数(BIS)的影响。方法选取行全麻乳腺改良根治手术的患者28例,咪达唑仑0.05 mg/kg、丙泊酚2 mg/kg和芬太尼2μg/kg麻醉诱导,患者失去意识后静脉推注罗库溴铵0.6μg/kg,肌松完全后行气管内插管,吸入七氟醚,泵注瑞芬太尼2μg/kg维持麻醉。将28例患者分成观察组与对照组,脑电双频谱指数(BIS)稳定后观察组患者给予静脉推注0.4μg/kg右旋美托嘧啶与生理盐水稀释的5 ml药物,而对照组患者静脉推注5 m1的生理盐水。对两组患者入室后、给药前、给药后5、10、15、30 min脑电双频谱指数(BIS)的变化进行对比性分析。结果观察组患者脑电双频谱指数逐步下降,30min时下降至(41.6±5.1)。而对照组患者脑电双频谱指数无明显变化。结论七氟醚复合瑞芬太尼麻醉期间应用右旋美托嘧啶药物,有助于降低脑电双频谱指数,增加麻醉深度。Objective To observere the effect of dexmedetomidine on the depth of anesthesia during sevoflrane combined with remifentanil .Methods Twenty-eight AS-AⅠ~Ⅱfemal patients with breast cancer , scheduled for radical mammotomy , were random-ly assigned to receive sevoflrane inhalation combined with remifentanil anesthesia .Anesthes-ia was induced with midazolam 0.05 mg/kg,fentanyl 2 μg/kg and propofol 2 mg/kg.T-racheal intubation was facilitated with rocuronium 0.6 mg/kg.Brain electrical double spectrum index （BIS） of all the patients were observed , After the BIS was maitained for （50 ＆#177;5）, patients were randomly di-vided into observation group and control group , the observa-tion group patients give 0.4 μg/kg dexmedetomi-dine saline dilution 5 ml, and control gro-up patients were given 5 ml of saline.The BIS of entering operating room, beforegiving dexmedetomidine and after giving dexmedetomidine 5,10,15,30 min were recorded.Re-sults After inducing , the BIS of the two groups were decline ,after giving dexmedetomidi-ne, the BIS of observa-tion group patients was decone continuly ,but the BIS of control group did not altered obviously .Conclusion During sevoflrane combined with remifentanil anesthesia , giving dexmedetomidine can reduce electrical double spectrum index ,inhence de-pth of anesthesia .

关 键 词：乳腺改良根治术 七氟醚 瑞芬太尼 右旋美托嘧啶 麻醉深度 

分 类 号：R614[医药卫生—麻醉学]